Plasma lncRNA LIPCAR Expression Levels Associated with Neurological Impairment and Stroke Subtypes in Patients with Acute Cerebral Infarction: A Prospective Observational Study with a Control Group

• Published in: Neurology and therapy 2023-08, Vol.12 (4), p.1385-1398
• Main Authors: Liu, Zhong-zhong, Lin, Wen-juan, Feng, Yue, Huang, Cong-li, Yan, Yin-fang, Guo, Wei-yan, Zhang, Huan, Lei, Zhen, Lu, Qing-li, Liu, Pei, Lin, Xue-mei, Wu, Song-di
• Format: Article
• Language: English
• Subjects: Acute cerebral infarction; Biomarker; Brief Report; Internal Medicine; Long non-coding RNA; Medicine; Medicine & Public Health; Neurology; Prognostic; Subtypes
• ISSN: 2193-8253; 2193-6536
• DOI: 10.1007/s40120-023-00482-9

Introduction This prospective observational study with a control group aimed to compare the plasma levels of long non-coding RNA (lncRNA) LIPCAR between patients with acute cerebral infarction (ACI) and healthy controls, and to assess the prognostic abilities of LIPCAR for adverse outcomes of patients with ACI at 1-year follow-up. Methods Eighty patients with ACI, of whom 40 had large artery atherosclerosis (LAA) and 40 had cardioembolism (CE) and who were hospitalized at Xi'an No. 1 Hospital from July 2019 to June 2020, were selected as the case group. Age- and sex-matched non-stroke patients from the same hospital throughout the same time period were chosen as the control group. Real-time quantitative reverse transcription polymerase chain reaction was used to measure the levels of plasma lncRNA LIPCAR. The correlations of LIPCAR expression among the LAA, CE, and control groups were assessed using Spearman’s correlation analysis. Curve fitting and multivariate logistic regression were used to analyze the LIPCAR levels and 1-year adverse outcomes of patients with ACI and its subtypes. Results The expression of plasma LIPCAR in the case group was noticeably higher than that of the control group (2.42 ± 1.49 vs. 1.00 ± 0.47, p