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Transcribed Ultraconserved Regions in Cancer
Transcribed ultraconserved regions are putative lncRNA molecules that are transcribed from DNA that is 100% conserved in human, mouse, and rat genomes. This is notable, as lncRNAs are typically poorly conserved. TUCRs remain very understudied in many diseases, including cancer. In this review, we su...
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| Published in: | Cells (Basel, Switzerland) Switzerland), 2022-05, Vol.11 (10), p.1684 |
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| Main Authors: | , , , , , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c481t-75cae2be1c51354189c74064436424df54848119653ab424ac79f2431d8c9e1f3 |
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| cites | cdi_FETCH-LOGICAL-c481t-75cae2be1c51354189c74064436424df54848119653ab424ac79f2431d8c9e1f3 |
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| container_issue | 10 |
| container_start_page | 1684 |
| container_title | Cells (Basel, Switzerland) |
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| creator | Gibert, Jr, Myron K Sarkar, Aditya Chagari, Bilhan Roig-Laboy, Christian Saha, Shekhar Bednarek, Sylwia Kefas, Benjamin Hanif, Farina Hudson, Kadie Dube, Collin Zhang, Ying Abounader, Roger |
| description | Transcribed ultraconserved regions are putative lncRNA molecules that are transcribed from DNA that is 100% conserved in human, mouse, and rat genomes. This is notable, as lncRNAs are typically poorly conserved. TUCRs remain very understudied in many diseases, including cancer. In this review, we summarize the current literature on TUCRs in cancer with respect to expression deregulation, functional roles, mechanisms of action, and clinical perspectives. |
| doi_str_mv | 10.3390/cells11101684 |
| format | article |
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This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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Sarkar, Aditya ; Chagari, Bilhan ; Roig-Laboy, Christian ; Saha, Shekhar ; Bednarek, Sylwia ; Kefas, Benjamin ; Hanif, Farina ; Hudson, Kadie ; Dube, Collin ; Zhang, Ying ; Abounader, Roger</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-75cae2be1c51354189c74064436424df54848119653ab424ac79f2431d8c9e1f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Cancer</topic><topic>Cell cycle</topic><topic>Conserved Sequence - genetics</topic><topic>DNA</topic><topic>DNA methylation</topic><topic>Gene loci</topic><topic>Genome</topic><topic>Genomes</topic><topic>Leukemia</topic><topic>long non-coding RNA</topic><topic>Mice</topic><topic>Mutation</topic><topic>Neoplasms - genetics</topic><topic>Non-coding RNA</topic><topic>Proteins</topic><topic>Rats</topic><topic>Review</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Long Noncoding - metabolism</topic><topic>TUCR</topic><topic>ultraconserved</topic><topic>X chromosomes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gibert, Jr, Myron K</creatorcontrib><creatorcontrib>Sarkar, Aditya</creatorcontrib><creatorcontrib>Chagari, Bilhan</creatorcontrib><creatorcontrib>Roig-Laboy, Christian</creatorcontrib><creatorcontrib>Saha, Shekhar</creatorcontrib><creatorcontrib>Bednarek, Sylwia</creatorcontrib><creatorcontrib>Kefas, Benjamin</creatorcontrib><creatorcontrib>Hanif, Farina</creatorcontrib><creatorcontrib>Hudson, Kadie</creatorcontrib><creatorcontrib>Dube, Collin</creatorcontrib><creatorcontrib>Zhang, Ying</creatorcontrib><creatorcontrib>Abounader, Roger</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Biological Sciences</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Cells (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gibert, Jr, Myron K</au><au>Sarkar, Aditya</au><au>Chagari, Bilhan</au><au>Roig-Laboy, Christian</au><au>Saha, Shekhar</au><au>Bednarek, Sylwia</au><au>Kefas, Benjamin</au><au>Hanif, Farina</au><au>Hudson, Kadie</au><au>Dube, Collin</au><au>Zhang, Ying</au><au>Abounader, Roger</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcribed Ultraconserved Regions in Cancer</atitle><jtitle>Cells (Basel, Switzerland)</jtitle><addtitle>Cells</addtitle><date>2022-05-19</date><risdate>2022</risdate><volume>11</volume><issue>10</issue><spage>1684</spage><pages>1684-</pages><issn>2073-4409</issn><eissn>2073-4409</eissn><abstract>Transcribed ultraconserved regions are putative lncRNA molecules that are transcribed from DNA that is 100% conserved in human, mouse, and rat genomes. 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| ispartof | Cells (Basel, Switzerland), 2022-05, Vol.11 (10), p.1684 |
| issn | 2073-4409 2073-4409 |
| language | eng |
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| subjects | Animals Cancer Cell cycle Conserved Sequence - genetics DNA DNA methylation Gene loci Genome Genomes Leukemia long non-coding RNA Mice Mutation Neoplasms - genetics Non-coding RNA Proteins Rats Review RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism TUCR ultraconserved X chromosomes |
| title | Transcribed Ultraconserved Regions in Cancer |
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