The chain-mediating effect of Crp, BMI on the relationship between dietary intake of live microbes and hyperlipidaemia

Inflammation and obesity are the risk factors for hyperlipidaemia. Nonetheless, research regarding the association between dietary live microbes intake and hyperlipidaemia is lacking. Therefore, this study focused on revealing the relationship between them and mediating roles of inflammation and obe...

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Bibliographic Details
Published in:Lipids in health and disease 2024-05, Vol.23 (1), p.130-130, Article 130
Main Authors: Chen, Jingyi, Fang, Shuhua, Huo, Jinlin, Yang, Nian
Format: Article
Language:English
Subjects:
Adult
Analysis
Antilipemic agents
B cells
Body Mass Index
C-reactive protein
C-Reactive Protein - metabolism
Cardiovascular diseases
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Composition
Diet
Dosage and administration
Female
Health aspects
Humans
Hyperlipidaemia
Hyperlipidemia
Hyperlipidemias - blood
Hyperlipidemias - diet therapy
Inflammation
Inflammation - blood
Live microbes
Low density lipoproteins
Male
Measurement
Mediation
Medical research
Medicine, Experimental
Microbiota (Symbiotic organisms)
Microorganisms
Middle Aged
NHANES
Nutrition Surveys
Obesity
Obesity - blood
Obesity - diet therapy
Prevention
Risk Factors
Surveys
Triglycerides - blood
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Summary:Inflammation and obesity are the risk factors for hyperlipidaemia. Nonetheless, research regarding the association between dietary live microbes intake and hyperlipidaemia is lacking. Therefore, this study focused on revealing the relationship between them and mediating roles of inflammation and obesity. Totally 16,677 subjects were enrolled from the National Health and Nutrition Examination Survey (NHANES) (1999-2010 and 2015-2020). To explore the correlation between live microbes and hyperlipidaemia as well as blood lipid levels, respectively, multiple logistic regression and linear regression were employed. Furthermore, the mediating roles of body mass index (BMI), C-reactive protein (Crp) and their chain effect were explored through mediating analysis. High dietary live microbes intake was the protective factor for hyperlipidaemia. In addition, high dietary live microbes intake exhibited a positive relationship to the high-density lipoprotein cholesterol (HDL-C) among males (β = 2.52, 95% CI: 1.29, 3.76, P 
ISSN:1476-511X
1476-511X
DOI:10.1186/s12944-024-02107-y