Static magnetic field stimulation over motor cortex modulates resting functional connectivity in humans

Focal application of transcranial static magnetic field stimulation (tSMS) over the human motor cortex induces local changes in cortical excitability. Whether tSMS can also induce distant network effects, and how these local and distant effects may vary over time, is currently unknown. In this study...

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Published in:Scientific reports 2022-05, Vol.12 (1), p.7834-7834, Article 7834
Main Authors: Soto-León, Vanesa, Torres-Llacsa, Mabel, Mordillo-Mateos, Laura, Carrasco-López, Carmen, Pineda-Pardo, José A., Velasco, Ana I., Abad-Toribio, Laura, Tornero, Jesús, Foffani, Guglielmo, Strange, Bryan A., Oliviero, Antonio
Format: Article
Language:English
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631/378
631/378/1697
Cortex (motor)
Excitability
Functional magnetic resonance imaging
Humanities and Social Sciences
Magnetic fields
multidisciplinary
Science
Science (multidisciplinary)
Sensorimotor integration
Visual system
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Summary:Focal application of transcranial static magnetic field stimulation (tSMS) over the human motor cortex induces local changes in cortical excitability. Whether tSMS can also induce distant network effects, and how these local and distant effects may vary over time, is currently unknown. In this study, we applied 10 min tSMS over the left motor cortex of healthy subjects using a real/sham parallel design. To measure tSMS effects at the sensori-motor network level, we used resting-state fMRI. Real tSMS, but not sham, reduced functional connectivity within the stimulated sensori-motor network. This effect of tSMS showed time-dependency, returning to sham levels after the first 5 min of fMRI scanning. With 10 min real tSMS over the motor cortex we did not observe effects in other functional networks examined (default mode and visual system networks). In conclusion, 10 min of tSMS over a location within the sensori-motor network reduces functional connectivity within the same functional network.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-11859-5