Association between estimated pulse wave velocity and the risk of mortality in patients with subarachnoid hemorrhage: a retrospective cohort study based on the MIMIC database

• Published in: BMC neurology 2024-10, Vol.24 (1), p.408-12, Article 408
• Main Authors: Chen, Min, Fan, Hongyang, Xie, Lili, Zhou, Li, Chen, Yingzhu
• Format: Article
• Language: English
• Subjects: 1-year mortality; 30-day mortality; Adult; Age; Aged; Blood pressure; Cardiovascular diseases; Care and treatment; Chronic obstructive pulmonary disease; Cohort analysis; Cohort Studies; Databases, Factual - trends; Diabetes mellitus; ePWV; Female; Humans; Hypertension; Intensive care; Liver diseases; Lung diseases; Male; Medical prognosis; Middle Aged; MIMIC database; Mortality; Patient outcomes; Patients; Pulse Wave Analysis - methods; Renal failure; Retrospective Studies; SAH; Sepsis; Software; Stroke; Structured Query Language-SQL; Subarachnoid hemorrhage; Subarachnoid Hemorrhage - diagnosis; Subarachnoid Hemorrhage - mortality; Subarachnoid Hemorrhage - physiopathology; Surgery; Variance analysis; Vascular Stiffness - physiology; Velocity; Ventilators
• ISSN: 1471-2377; 1471-2377
• DOI: 10.1186/s12883-024-03897-5

The estimated pulse wave velocity (ePWV) is a recently developed, simple and useful tool to measure arterial stiffness and to predict long-term cardiovascular mortality. However, the association of ePWV with mortality risk in patients with subarachnoid hemorrhage (SAH) is unclear. Herein, this study aims to assess the potential prediction value of ePWV on short- and long-term mortality of SAH patients. Data of adult patients with no traumatic SAH were extracted from the Medical Information Mart for Intensive Care (MIMIC) III and IV database in this retrospective cohort study. Weighted univariate and multivariable Cox regression analyses were used to explore the associations of ePWV levels with 30-day mortality and 1-year mortality in SAH patients. The evaluation indexes were hazard ratios (HRs) and 95% confidence intervals (CIs). In addition, subgroup analyses of age, the sequential organ failure assessment (SOFA) score, surgery, atrial fibrillation (AF), renal failure (RF), hepatic diseases, chronic obstructive pulmonary disease (COPD), sepsis, hypertension, and diabetes mellitus (DM) were also performed. Among 1,481 eligible patients, 339 died within 30 days and 435 died within 1 year. After adjusting for covariates, ePWV ≥ 12.10 was associated with higher risk of both 30-day mortality (HR = 1.77, 95%CI: 1.17-2.67) and 1-year mortality (HR = 1.97, 95%CI: 1.36-2.85), compared to ePWV