Spectrofluorometric investigations on the solvent effects on the photocyclization reaction of diclofenac

The solvent effects on the photochemical conversion rate of the photosensitizing drug diclofenac (DCF) were investigated using steady-state fluorescence spectroscopy. The spectral information obtained for the photochemical reaction of DCF in a set of neat solvents demonstrates that the photoconversi...

Full description

Saved in:
Bibliographic Details
Published in:Heliyon 2023-11, Vol.9 (11), p.e20767-e20767, Article e20767
Main Authors: Bani-Yaseen, Abdulilah Dawoud, Al-Zoubi, Raed M., Shkoor, Mohanad
Format: Article
Language:English
Subjects:
Diclofenac
Fluorescence
Photoconversion
Solvatochromic models
Solvent effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The solvent effects on the photochemical conversion rate of the photosensitizing drug diclofenac (DCF) were investigated using steady-state fluorescence spectroscopy. The spectral information obtained for the photochemical reaction of DCF in a set of neat solvents demonstrates that the photoconversion reaction rate of DCF is not only medium polarity dependent but also hydrogen-bonding dependent. The solvent effects were qualitatively and quantitatively assessed employing various solvatochromic models, including multi-parameter linear regression analysis (MLRA). Interestingly, the MLRA results (R = 0.99) revealed that the photoconversion rate increases with increasing solvent polarizability (π*) and H-bond donor capability (α), whereas the rate decreases with increasing hydrogen-bond acceptor capability (β). However, predominant effect of the solvent acidity compared to basicity and polarizability was observed. A hypothesis rationalizing the effects of H-bonding and medium polarity on DCF photoconversion reaction is presented and discussed.
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2023.e20767