A novel biomarker renalase and its relationship with its substrates in schizophrenia

Schizophrenia, particularly the form related to excessive dopamine (DA), is a chronic psychotic disorder affecting millions of people worldwide. Renalase metabolizes its catecholamine (CA) substrates, including DA, suggesting that there might be an association between renalase levels and schizophren...

Full description

Saved in:
Bibliographic Details
Published in:Journal of medical biochemistry 2019-07, Vol.38 (3), p.299-305
Main Authors: Catak, Zekiye, Kocdemir, Esra, Ugur, Kader, Yardim, Meltem, Sahin, İbrahim, Kaya, Hilal, Aydin, Suleyman
Format: Article
Language:English
Subjects:
Biomarkers
Catecholamine
Catecholamines
Confidence intervals
dopamin
Dopamine
Enzyme-linked immunosorbent assay
Enzymes
Epinephrine
kateholamini
Mental disorders
Norepinephrine
Original Paper
renalase
renalaze
Schizophrenia
shizofrenija
Substrates
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Schizophrenia, particularly the form related to excessive dopamine (DA), is a chronic psychotic disorder affecting millions of people worldwide. Renalase metabolizes its catecholamine (CA) substrates, including DA, suggesting that there might be an association between renalase levels and schizophrenia occurrence. Therefore, the current study aimed to evaluate the renalase and CA levels in the serum of patients with schizophrenia. The study was conducted with thirty-three schizophrenia patients and an age- and gender-matched group of thirty-one controls. Renalase and CA levels were measured by using an enzyme-linked immunosorbent assay (ELISA). Renalase levels were significantly lower in the schizophrenia patients than in the control group (
ISSN:1452-8258
1452-8266
1452-8266
DOI:10.2478/jomb-2018-0031