The relationship between phosphorus retention and fibroblast growth factor 23 in broiler breeders

Previous studies with broiler breeders indicate a P retention threshold when fed daily dietary levels of non-phytate P (NPP) exceeding 320 mg. Fibroblast growth factor 23 (FGF23) is a hormone secreted by osteocytes which modulates P retention and could be the biological agent which controls the P th...

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Published in:Poultry science 2024-08, Vol.103 (8), p.103889, Article 103889
Main Authors: Magnuson, A.D., Boonsinchai, N., Caldas, J., England, J., Coon, C.
Format: Article
Language:English
Subjects:
Animal Feed - analysis
Animal Nutritional Physiological Phenomena
Animals
Avian Proteins - metabolism
biomarker
broiler breeder
calcium
Chickens - metabolism
Chickens - physiology
Diet - veterinary
Dose-Response Relationship, Drug
Female
Fibroblast Growth Factor-23
Fibroblast Growth Factors - blood
Fibroblast Growth Factors - metabolism
Male
METABOLISM AND NUTRITION
phosphorus
Phosphorus - metabolism
Phosphorus, Dietary - administration & dosage
Phosphorus, Dietary - metabolism
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Summary:Previous studies with broiler breeders indicate a P retention threshold when fed daily dietary levels of non-phytate P (NPP) exceeding 320 mg. Fibroblast growth factor 23 (FGF23) is a hormone secreted by osteocytes which modulates P retention and could be the biological agent which controls the P threshold in breeders. To evaluate the relationship between FGF23 and the P retention threshold, a 4-wk study with 32-wk-old breeders was conducted with 6 dietary treatments with daily NPP intake of 216 to 576 mg/d/h with increments of 80 mg/kg diet. The goals were 1) to elucidate how plasma FGF23 corresponds with the P retention threshold in broiler breeders and 2) to determine the amount of P for optimal egg production and bone health. Results showed that between daily 288 mg and 360 mg dietary NPP intake, P retention decreased from 33 to 26% but FGF23 levels increased from 130 pg/mL to 220 pg/mL with increasing NPP. The elevation of plasma FGF23 between the range of 288 mg to 360 mg dietary NPP/d intake suggests that FGF23 is related to the P retention threshold and may be the major hormone for regulating physiological P levels when intake of daily dietary P levels are increased above 288 mg NPP.
ISSN:0032-5791
1525-3171
1525-3171
DOI:10.1016/j.psj.2024.103889