Altered Morphologies and Functions of the Olfactory Bulb and Hippocampus Induced by miR-30c

Adult neurogenesis is considered to contribute to a certain degree of plasticity for the brain. However, the effects of adult-born neurons on the brain are still largely unknown. Here, we specifically altered the expression of miR-30c in the subventricular zone (SVZ) and dentate gyrus (DG) by stereo...

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Bibliographic Details
Published in:Frontiers in neuroscience 2016-05, Vol.10, p.207-207
Main Authors: Sun, Tingting, Li, Tianpeng, Davies, Henry, Li, Weiyun, Yang, Jing, Li, Shanshan, Ling, Shucai
Format: Article
Language:English
Subjects:
adult neurogenesis
Dentate Gyrus
Epigenetics
Experiments
Food
Hippocampus
Laboratory animals
Lentivirus
Medical research
Memory
MicroRNAs
miRNA
Neurogenesis
Neurosciences
Olfaction
Olfactory Bulb
Olfactory thresholds
Physiology
semaphorin3A
Spatial memory
Stem cells
Subventricular zone
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Summary:Adult neurogenesis is considered to contribute to a certain degree of plasticity for the brain. However, the effects of adult-born neurons on the brain are still largely unknown. Here, we specifically altered the expression of miR-30c in the subventricular zone (SVZ) and dentate gyrus (DG) by stereotaxic injection with their respective up- and down-regulated lentiviruses. Results showed an increased level of miR-30c enhanced adult neurogenesis by prompting cell-cycles of stem cells, whereas down-regulated miR-30c led to the opposite results. When these effects of miR-30c lasted for 3 months, we detected significant morphological changes in the olfactory bulb (OB) and lineage alteration in the hippocampus. Tests of olfactory sensitivity and associative and spatial memory showed that a certain amount of adult-born neurons are essential for the normal functions of the OB and hippocampus, but there also exist redundant newborn neurons that do not further improve the functioning of these areas. Our study revealed the interactions between miRNA, adult neurogenesis, brain morphology and function, and this provides a novel insight into understanding the role of newborn neurons in the adult brain.
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2016.00207