Acute Toxicity and Antioxidant and Antibacterial Activities of Kyllinga polyphylla Willd. ex Kunth, Cyperaceae Family

Kyllinga polyphylla Willd. ex Kunth. (KP) is a wild herb commonly distributed in the Mekong Delta, Vietnam. This study was carried out to evaluate the antibacterial and antioxidant activities and acute toxicity of KP before conducting studies at the in vivo level. All parts of KP had the free radica...

Full description

Saved in:
Bibliographic Details
Published in:Journal of toxicology 2024-01, Vol.2024, p.3543828-13
Main Authors: Nguyen, Van-Ay, Phung, Thi-Hang, Kieu, Thi-Diem-Trang, Nguyen, Trong-Hong-Phuc
Format: Article
Language:English
Subjects:
Acute toxicity
Amoxicillin
Antibacterial activity
Antibacterial agents
Antibiotics
Antioxidants
Biocompatibility
Body weight
Drug dosages
Drug resistance in microorganisms
E coli
Efficiency
Ethanol
Experiments
Free radicals
Gram-positive bacteria
Hematology
In vivo methods and tests
Kyllinga
Medical research
Medical treatment
Medicine, Experimental
Methanol
Physiology
Phytochemicals
Pore size
Scavenging
Tetracycline
Tetracyclines
Toxicity
Toxicity testing
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Kyllinga polyphylla Willd. ex Kunth. (KP) is a wild herb commonly distributed in the Mekong Delta, Vietnam. This study was carried out to evaluate the antibacterial and antioxidant activities and acute toxicity of KP before conducting studies at the in vivo level. All parts of KP had the free radical scavenging capacity of DPPH, in which the root methanol extract had the best antioxidant capacity (EC50 = 9.54 ± 0.37 μg/mL). Most of the extracts had a wide range of antibacterial spectra. The methanol and ethanol extracts (200 mg/mL) have ability to resist eight common bacterial strains (including Staphylococcus aureus, Listeria innocua, Bacillus subtilis, Bacillus cereus, Escherichia coli, Salmonella sp., Pseudomonas aeruginosa, and Enterococcus faecalis), which is equivalent to the antibacterial activity of amoxicillin and tetracycline at a concentration of 1 mg/mL. KP extracts did not cause death at a dose of 5000 mg/kg body weight and did not significantly change the biochemical, hematological, as well as histological structures of internal organs in toxicity-tested mice in comparison with the control. The research results showed that KP should be more interested in research that supports disease treatment, synthetic extraction of antibiotics, or other in vivo studies.
ISSN:1687-8191
1687-8205
DOI:10.1155/2024/3543828