Endurance exercise training decreased serum levels of surfactant protein D and improved aerobic fitness of obese women with type-2 diabetes

• Published in: Diabetology and metabolic syndrome 2017-09, Vol.9 (1), p.74-74, Article 74
• Main Authors: Rezaei, Sajjad, Shamsi, Mahdieh Molanouri, Mahdavi, Mehdi, Jamali, Azadeh, Prestes, Jonato, Tibana, Ramires Alsamir, Navalta, James Wilfred, Voltarelli, Fabrício Azevedo
• Format: Article
• Language: English
• Subjects: Aerobics; Analysis; Body mass index; Cardiorespiratory fitness; Cardiovascular disease; Care and treatment; Data processing; Diabetes; Diabetes mellitus; Exercise; Exercise training; Fitness training programs; Gene expression; Glucose; Health aspects; Heart rate; Insulin; Insulin resistance; Leptin; Metabolism; Obesity; Physical fitness; Physical training; Protein D; Proteins; Rodents; Serum levels; Surfactant protein D; Surfactants; Type 2 diabetes; Type-2 diabetes mellitus; Weight control; Womens health
• ISSN: 1758-5996; 1758-5996
• DOI: 10.1186/s13098-017-0273-6

Surfactant protein D (SP-D) is a member of the collectin family and is an important component of the pulmonary innate host defense. To find the relationship between exercise training and SP-D in diabetes, we examined the possible effects of a 10-week endurance exercise-training program on serum levels of SP-D, leptin, lipid profile and insulin resistance in obese women with type-2 diabetes (T2DM). Twenty-two obese women with T2DM were randomly assigned to either exercise training (ET) or control (C) group. A subject dropped from ET group due to personal reasons and 1 subject dropped from C group due to commitment to experiments conditions. A total of twenty obese women with T2DM were randomly assigned into endurance exercise training (ET = 10) and control (C = 10) groups. The training group underwent a progressive endurance-training program for 10 weeks (running on a treadmill for 30-55 min/day at 50-75% heart rate reserve) and the control group did not participate in any exercise program. Venous blood samples were collected from both groups before and 72 h after the last session of exercise training for analysis of serum SP-D, leptin, lipid profile, glucose and insulin. Data were analyzed using 2 (group: control, endurance training) × 2 (time: pre, post) ANOVA with repeated measures on the second factor. Absolute changes from rest (∆ baseline) values were calculated according to the following formula: ((measure-baseline)·baseline-1)·100. Percent change between groups was analyzed using independent t-tests (p