Exposure to Perfluoroalkyl Substances During Pregnancy and Fetal BDNF Level: A Prospective Cohort Study

Humans are widely exposed to environmental perfluoroalkyl substances (PFAS), which may affect fetal neurodevelopment. Brain-derived neurotrophic factor (BDNF) is an important factor in neurodevelopment, but its role in PFAS-induced neurotoxicity is unclear. We investigated the association between pr...

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Published in:Frontiers in endocrinology (Lausanne) 2021-06, Vol.12, p.653095-653095
Main Authors: Yu, Guoqi, Luo, Fei, Nian, Min, Li, Shuman, Liu, Bin, Feng, Liping, Zhang, Jun
Format: Article
Language:English
Subjects:
Adult
BDNF
Brain-Derived Neurotrophic Factor - blood
China
Chromatography, High Pressure Liquid
cohort
Endocrinology
Environmental Pollutants - blood
Female
Fetal Blood - metabolism
fetus
Fluorocarbons - adverse effects
gender difference
Humans
Linear Models
Longitudinal Studies
Male
Maternal Exposure
Mercury - blood
Mercury - toxicity
perfluoroalkyl substances
Pregnancy
Prospective Studies
Sex Factors
Spectrophotometry, Atomic
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Summary:Humans are widely exposed to environmental perfluoroalkyl substances (PFAS), which may affect fetal neurodevelopment. Brain-derived neurotrophic factor (BDNF) is an important factor in neurodevelopment, but its role in PFAS-induced neurotoxicity is unclear. We investigated the association between prenatal PFAS exposure and fetal BDNF level in the umbilical cord blood in a large prospective cohort. A total of 725 pregnant women who participated in the Shanghai Birth Cohort were included. 10 PFAS were measured by high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS-MS) in the plasma samples of early pregnancy. The BDNF level was determined by ELISA. The concentration of total mercury (Hg) in the umbilical cord blood was tested by cold vapor atomic absorption spectrometry (AAS) and included as a main confounder, along with other covariates. Multiple linear regression was used to explore the associations between PFAS concentrations and BDNF level. Quantile-based g-computation was applied to explore the joint and independent effects of PFAS on BDNF level. The mean BDNF level in the total population was 10797 (±4713) pg/ml. Male fetuses had a higher level than female fetuses (
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2021.653095