Analysis of Epstein-Barr Virus (EBV) and PD-L1 Expression in Nasopharyngeal Carcinoma Patients in a Non-Endemic Region

The purpose of this study was to evaluate the status of Epstein-Barr virus (EBV) infection and the expression of programmed cell death ligand-1 (PD-L1) in tumor samples from patients with nasopharyngeal carcinoma (NPC). Evaluation of EBV infection was performed through the detection of EBV-encoded s...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-10, Vol.23 (19), p.11720
Main Authors: Dias, Josiane M, Santana, Iara V V, da Silva, Vinicius D, Carvalho, André L, Arantes, Lidia M R B
Format: Article
Language:English
Subjects:
Alcoholism
Antigens
Apoptosis
B7-H1 Antigen - metabolism
Cancer
Cell death
Epstein-Barr virus
Epstein-Barr Virus Infections - complications
Epstein–Barr virus (EBV)
Herpesvirus 4, Human - metabolism
Histology
Humans
Hybridization
Immune checkpoint
Immunohistochemistry
Immunotherapy
Infections
Ligands
Multivariate analysis
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms
non-endemic region
Patients
PD-L1 protein
Population
programmed cell death ligand-1 (PD-L1)
Smoking
Statistical analysis
Survival analysis
Throat cancer
Tumors
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Summary:The purpose of this study was to evaluate the status of Epstein-Barr virus (EBV) infection and the expression of programmed cell death ligand-1 (PD-L1) in tumor samples from patients with nasopharyngeal carcinoma (NPC). Evaluation of EBV infection was performed through the detection of EBV-encoded small ribonucleic acids (EBER) by in situ hybridization, and PD-L1 expression was performed through immunohistochemistry. In total, 124 samples were evaluated for EBER and 120 for PD-L1 expression. A total of 86.3% of cases were positive for EBER and 55.8% were positive for PD-L1. There was a correlation between EBER positivity and the presence of undifferentiated carcinoma histology ( = 0.007) as well as the absence of tobacco history ( = 0.019). There was a correlation between PD-L1 expression and EBER positivity ( = 0.004). There was no statistically significant difference between overall survival (OS) and EBER ( = 0.290) or PD-L1 ( = 0.801) expression. This study corresponds to one of the largest cohorts of NPC in a non-endemic region. Phase III studies with checkpoint inhibitors are ongoing and may provide more data about the role of PD-L1 expression in this disease.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms231911720