Impact of pneumococcal conjugate vaccine on the carriage density of Streptococcus pneumoniae and Staphylococcus aureus in children living with HIV: a nested case-control study

Nasopharyngeal colonization density of (pneumococcus) is associated with disease severity and transmission. Little is known about the density of pneumococcal carriage in children with HIV (CLH). Pneumococcal vaccines may impact the density of pneumococcus and competing microbes within the nasopharyn...

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Bibliographic Details
Published in:Human vaccines & immunotherapeutics 2020-08, Vol.16 (8), p.1918-1922
Main Authors: Khan, Tila, Das, Ranjan Saurav, Arya, Bikas K, Chaudhary, Amrita, Chatterjee, Jyotirmoy, Das Bhattacharya, Sangeeta
Format: Article
Language:English
Subjects:
Brief Report
Carrier State - epidemiology
Case-Control Studies
Child
colonization density
hiv
HIV Infections - complications
Humans
Infant
Nasopharynx
nasopharynx microbiology
pcv13
Pilot Projects
Pneumococcal Infections - epidemiology
Pneumococcal Infections - prevention & control
Pneumococcal Vaccines
Prospective Studies
Serogroup
Short Report
Staphylococcus aureus
Streptococcus pneumoniae
Vaccines, Conjugate
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Summary:Nasopharyngeal colonization density of (pneumococcus) is associated with disease severity and transmission. Little is known about the density of pneumococcal carriage in children with HIV (CLH). Pneumococcal vaccines may impact the density of pneumococcus and competing microbes within the nasopharynx. We examined the impact of one dose of PCV13 on carriage density of pneumococcus and , in CLH, HIV-uninfected children (HUC), and their unvaccinated parents. We conducted a pilot-nested case-control study, within a larger prospective cohort study, on the impact of PCV13, in families in West Bengal India. Quantitative real-time PCR was run on 147 nasopharyngeal swabs from 27 CLH and 23 HUC, and their parents, before and after PCV13 immunization. CLH had higher median pneumococcal carriage density, compared to HUC: 6.28 × 10 copies/mL vs. 2.11 × 10 copies/mL ( = .005). Following one dose of PCV13, pneumococcal densities dropped in both groups, with an increase in carriage to 80% from 48% in CLH, and to 60% in HUC from 25%. While limited in sample size, this pilot study shows that CLH carried higher densities of pneumococcus. PCV13 was associated with a decrease in pneumococcal density and a temporal increase in carriage regardless of HIV status.
ISSN:2164-5515
2164-554X
DOI:10.1080/21645515.2019.1706411