Loading…

Synthetic biology to revive microbial natural product discovery

In turn, these interactions can help stabilize ecosystems and affect the health and disease of hosts. [...]MNPs have been critical in human medicine, serving as an important source for the discovery and development of drugs to treat infectious diseases, cancers, high cholesterol, and so on. To produ...

Full description

Saved in:
Bibliographic Details
Published in:mLife 2023-06, Vol.2 (2), p.123-125
Main Author: Tang, Xiaoyu
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In turn, these interactions can help stabilize ecosystems and affect the health and disease of hosts. [...]MNPs have been critical in human medicine, serving as an important source for the discovery and development of drugs to treat infectious diseases, cancers, high cholesterol, and so on. To produce natural products, biosynthetic enzymes work sequentially to form an assembly line, where pools of simple chemical building blocks, such as amino acids, fatty acids, and sugars, are activated and incorporated to form the final molecules. Over the past few decades, the natural product biosynthesis community has dedicated tremendous efforts to discovering and elucidating natural product biosynthetic enzymes, which has advanced our biosynthetic knowledge to the point where we can predict almost any type of BGC (or even their putative chemical structures) from sequence data. By replacing the promoter regions of the main biosynthetic operons of silent BGCs with constitutive promoters, they observed the production of various natural products from these BGCs, including type I, II, and III polyketide synthases (PKSs), nonribosomal peptide synthetase (NRPS), hybrid PKS–NRPS, and phosphonate clusters.
ISSN:2770-100X
2097-1699
2770-100X
DOI:10.1002/mlf2.12071