XGEM: Predicting Essential miRNAs by the Ensembles of Various Sequence-Based Classifiers With XGBoost Algorithm

MicroRNAs (miRNAs) play vital roles in gene expression regulations. Identification of essential miRNAs is of fundamental importance in understanding their cellular functions. Experimental methods for identifying essential miRNAs are always costly and time-consuming. Therefore, computational methods...

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Bibliographic Details
Published in:Frontiers in genetics 2022-03, Vol.13, p.877409-877409
Main Authors: Min, Hui, Xin, Xiao-Hong, Gao, Chu-Qiao, Wang, Likun, Du, Pu-Feng
Format: Article
Language:English
Subjects:
CART
ensemble classifier
essential miRNA
Genetics
sequence features
XGBoost
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Summary:MicroRNAs (miRNAs) play vital roles in gene expression regulations. Identification of essential miRNAs is of fundamental importance in understanding their cellular functions. Experimental methods for identifying essential miRNAs are always costly and time-consuming. Therefore, computational methods are considered as alternative approaches. Currently, only a handful of studies are focused on predicting essential miRNAs. In this work, we proposed to predict essential miRNAs using the XGBoost framework with CART (Classification and Regression Trees) on various types of sequence-based features. We named this method as XGEM (XGBoost for essential miRNAs). The prediction performance of XGEM is promising. In comparison with other state-of-the-art methods, XGEM performed the best, indicating its potential in identifying essential miRNAs.
ISSN:1664-8021
1664-8021
DOI:10.3389/fgene.2022.877409