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Retrospective Analysis of Epidemiology, Risk Factors, and Outcomes of Health Care-Acquired Carbapenem-Resistant Klebsiella pneumoniae Bacteremia in a Chinese Tertiary Hospital, 2010–2019
Introduction In the present study, we aimed to describe the proportion of carbapenem-resistant Klebsiella pneumoniae bloodstream infection (CRKP-BSI) in KP-BSI in one Chinese tertiary hospital over 10 years and determine the risk factors and outcomes of CRKP-BSI. Methods We retrospectively analyzed...
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| Published in: | Infectious diseases and therapy 2023-02, Vol.12 (2), p.473-485 |
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| creator | Li, Meng Yang, Shanshan Yao, Hongwu Liu, Yunxi Du, Mingmei |
| description | Introduction
In the present study, we aimed to describe the proportion of carbapenem-resistant
Klebsiella pneumoniae
bloodstream infection (CRKP-BSI) in KP-BSI in one Chinese tertiary hospital over 10 years and determine the risk factors and outcomes of CRKP-BSI.
Methods
We retrospectively analyzed clinical and microbiological data of patients with KP-BSI from January 2010 to December 2019 to identify risk factors, clinical features, and outcomes using multivariate logistic regression analysis. KP-BSI only included monomicrobial BSI and health care-acquired BSI.
Results
Among the total 687 isolates of KP-BSI in this study, the rate of CRKP was 39.0% (268/687); this rate in the intensive care unit (ICU) was 65.6% and that in seven high-risk departments (including four ICUs, respiratory medicine, gastroenterology medicine, and hepatobiliary surgery) was 74.6%. The annual rate of CRKP in KP-BSI ranged from 0.0% in 2010 to 54.5% in 2019. The 28-day mortality was 36.2% in patients with CRKP-BSI and 11.7% in those with carbapenem-susceptible
K. pneumoniae
(CSKP) BSI. Multivariable logistic regression analysis showed that prior ICU stay (odds ratio [OR] 2.485,
P
|
| doi_str_mv | 10.1007/s40121-022-00732-7 |
| format | article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_23ac8b5a02074b148be2e14f70e74f42</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A737064514</galeid><doaj_id>oai_doaj_org_article_23ac8b5a02074b148be2e14f70e74f42</doaj_id><sourcerecordid>A737064514</sourcerecordid><originalsourceid>FETCH-LOGICAL-c607t-963a1ffc48f5ec7a9c3279e1aab3238c8f24e20d3d43e0fb731c96d8a16693f93</originalsourceid><addsrcrecordid>eNp9ks9u1DAQxiMEolXpC3BAlrhw2BT_SxxfkJZVSysqVarK2XKc8dYlsbd2Uqk33oHX4Wl4Ery7pWURQj7YY__m84z9FcVrgo8IxuJ94phQUmJKyxwyWopnxT4lkpU1a-jzh3VDqdwrDlO6wTjzDSdSvCz2WF1RzKjcL35cwhhDWoEZ3R2gudf9fXIJBYuOV66DwYU-LO9n6NKlr-hEmzHENEPad-hiGk0YYMOegu7Ha7TQEcq5uZ1chG4dtXoFHobyErLoqP2IPvfQJgd9r9HKwzQE7zSgj1kYYr5NI-eRRotr5yEBuoI4Oh3v0Wmu0Y26nyGKCf757Xue5KvihdV9gsOH-aD4cnJ8tTgtzy8-nS3m56WpsRhLWTNNrDW8sRUYoaVhVEggWreMssY0lnKguGMdZ4BtKxgxsu4aTepaMivZQXG21e2CvlGr6IZckgraqc1GiEulc52mB0WZNk1baUyx4C3hTQsUCLcCg-CW06z1Yau1mtoBOgN-jLrfEd098e5aLcOdkpJWdSWywLsHgRhuJ0ijGlwy6wf1EKakqKh4U0le1xl9-xd6E6aYvzhTTS0IqyUnT9RS5wactyHfa9aiai6YwDWvCM_U0T-oPNYeMcGDdXl_J4FuE0z2V4pgH3skWK0trLYWVtnCamNhtW7uzZ-v85jy27AZYFsg5SO_hPjU0n9kfwHga_zV</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2867136941</pqid></control><display><type>article</type><title>Retrospective Analysis of Epidemiology, Risk Factors, and Outcomes of Health Care-Acquired Carbapenem-Resistant Klebsiella pneumoniae Bacteremia in a Chinese Tertiary Hospital, 2010–2019</title><source>Publicly Available Content Database</source><source>Springer Nature - SpringerLink Journals - Fully Open Access </source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Li, Meng ; Yang, Shanshan ; Yao, Hongwu ; Liu, Yunxi ; Du, Mingmei</creator><creatorcontrib>Li, Meng ; Yang, Shanshan ; Yao, Hongwu ; Liu, Yunxi ; Du, Mingmei</creatorcontrib><description>Introduction
In the present study, we aimed to describe the proportion of carbapenem-resistant
Klebsiella pneumoniae
bloodstream infection (CRKP-BSI) in KP-BSI in one Chinese tertiary hospital over 10 years and determine the risk factors and outcomes of CRKP-BSI.
Methods
We retrospectively analyzed clinical and microbiological data of patients with KP-BSI from January 2010 to December 2019 to identify risk factors, clinical features, and outcomes using multivariate logistic regression analysis. KP-BSI only included monomicrobial BSI and health care-acquired BSI.
Results
Among the total 687 isolates of KP-BSI in this study, the rate of CRKP was 39.0% (268/687); this rate in the intensive care unit (ICU) was 65.6% and that in seven high-risk departments (including four ICUs, respiratory medicine, gastroenterology medicine, and hepatobiliary surgery) was 74.6%. The annual rate of CRKP in KP-BSI ranged from 0.0% in 2010 to 54.5% in 2019. The 28-day mortality was 36.2% in patients with CRKP-BSI and 11.7% in those with carbapenem-susceptible
K. pneumoniae
(CSKP) BSI. Multivariable logistic regression analysis showed that prior ICU stay (odds ratio [OR] 2.485,
P
< 0.001), hospital stay ≥ 30 days prior to BSI (OR 1.815,
P
= 0.007), prior mechanical ventilation (OR 2.020,
P
= 0.014), prior urinary catheter (OR 1.999,
P
= 0.003), prior carbapenem use (OR 3.840,
P
< 0.001), hepatobiliary disease (OR 2.943,
P
< 0.001), pancreatitis (OR 2.700,
P
= 0.026), and respiratory disease (OR 2.493,
P
= 0.009) were risk factors of CRKP-BSI. Patients with a first admission (OR 0.662,
P
= 0.046) had a lower percentage of CRKP-BSI.
Conclusion
The rapidly rising rate of CRKP-BSI in KP with high mortality requires increased attention. Exposure to carbapenems, ICU stay, invasive mechanical ventilation or urinary catheter, prolonged hospital stay, hepatobiliary disease, pancreatitis, and respiratory disease were found to be risk factors for CRKP-BSI. Strict control measures should be implemented to prevent the emergence and spread of CRKP, especially in high-risk departments.</description><identifier>ISSN: 2193-8229</identifier><identifier>EISSN: 2193-6382</identifier><identifier>DOI: 10.1007/s40121-022-00732-7</identifier><identifier>PMID: 36520329</identifier><language>eng</language><publisher>Cheshire: Springer Healthcare</publisher><subject>Antibiotics ; Carbapenem-resistant Klebsiella pneumoniae ; Catheters ; Epidemiology ; Health aspects ; Health care ; Hospitals ; Imipenem ; Infectious Diseases ; Internal Medicine ; Medical instruments ; Medicine ; Medicine & Public Health ; Mortality ; Original Research ; Pancreatitis ; Regression analysis ; Resistance rate ; Respiratory diseases ; Respiratory tract diseases ; Risk factors ; Ventilation ; Ventilators</subject><ispartof>Infectious diseases and therapy, 2023-02, Vol.12 (2), p.473-485</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>COPYRIGHT 2023 Springer</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c607t-963a1ffc48f5ec7a9c3279e1aab3238c8f24e20d3d43e0fb731c96d8a16693f93</citedby><cites>FETCH-LOGICAL-c607t-963a1ffc48f5ec7a9c3279e1aab3238c8f24e20d3d43e0fb731c96d8a16693f93</cites><orcidid>0000-0002-3768-2821</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2867136941/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2867136941?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25731,27901,27902,36989,36990,44566,53766,53768,74869</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36520329$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Meng</creatorcontrib><creatorcontrib>Yang, Shanshan</creatorcontrib><creatorcontrib>Yao, Hongwu</creatorcontrib><creatorcontrib>Liu, Yunxi</creatorcontrib><creatorcontrib>Du, Mingmei</creatorcontrib><title>Retrospective Analysis of Epidemiology, Risk Factors, and Outcomes of Health Care-Acquired Carbapenem-Resistant Klebsiella pneumoniae Bacteremia in a Chinese Tertiary Hospital, 2010–2019</title><title>Infectious diseases and therapy</title><addtitle>Infect Dis Ther</addtitle><addtitle>Infect Dis Ther</addtitle><description>Introduction
In the present study, we aimed to describe the proportion of carbapenem-resistant
Klebsiella pneumoniae
bloodstream infection (CRKP-BSI) in KP-BSI in one Chinese tertiary hospital over 10 years and determine the risk factors and outcomes of CRKP-BSI.
Methods
We retrospectively analyzed clinical and microbiological data of patients with KP-BSI from January 2010 to December 2019 to identify risk factors, clinical features, and outcomes using multivariate logistic regression analysis. KP-BSI only included monomicrobial BSI and health care-acquired BSI.
Results
Among the total 687 isolates of KP-BSI in this study, the rate of CRKP was 39.0% (268/687); this rate in the intensive care unit (ICU) was 65.6% and that in seven high-risk departments (including four ICUs, respiratory medicine, gastroenterology medicine, and hepatobiliary surgery) was 74.6%. The annual rate of CRKP in KP-BSI ranged from 0.0% in 2010 to 54.5% in 2019. The 28-day mortality was 36.2% in patients with CRKP-BSI and 11.7% in those with carbapenem-susceptible
K. pneumoniae
(CSKP) BSI. Multivariable logistic regression analysis showed that prior ICU stay (odds ratio [OR] 2.485,
P
< 0.001), hospital stay ≥ 30 days prior to BSI (OR 1.815,
P
= 0.007), prior mechanical ventilation (OR 2.020,
P
= 0.014), prior urinary catheter (OR 1.999,
P
= 0.003), prior carbapenem use (OR 3.840,
P
< 0.001), hepatobiliary disease (OR 2.943,
P
< 0.001), pancreatitis (OR 2.700,
P
= 0.026), and respiratory disease (OR 2.493,
P
= 0.009) were risk factors of CRKP-BSI. Patients with a first admission (OR 0.662,
P
= 0.046) had a lower percentage of CRKP-BSI.
Conclusion
The rapidly rising rate of CRKP-BSI in KP with high mortality requires increased attention. Exposure to carbapenems, ICU stay, invasive mechanical ventilation or urinary catheter, prolonged hospital stay, hepatobiliary disease, pancreatitis, and respiratory disease were found to be risk factors for CRKP-BSI. Strict control measures should be implemented to prevent the emergence and spread of CRKP, especially in high-risk departments.</description><subject>Antibiotics</subject><subject>Carbapenem-resistant Klebsiella pneumoniae</subject><subject>Catheters</subject><subject>Epidemiology</subject><subject>Health aspects</subject><subject>Health care</subject><subject>Hospitals</subject><subject>Imipenem</subject><subject>Infectious Diseases</subject><subject>Internal Medicine</subject><subject>Medical instruments</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mortality</subject><subject>Original Research</subject><subject>Pancreatitis</subject><subject>Regression analysis</subject><subject>Resistance rate</subject><subject>Respiratory diseases</subject><subject>Respiratory tract diseases</subject><subject>Risk factors</subject><subject>Ventilation</subject><subject>Ventilators</subject><issn>2193-8229</issn><issn>2193-6382</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9ks9u1DAQxiMEolXpC3BAlrhw2BT_SxxfkJZVSysqVarK2XKc8dYlsbd2Uqk33oHX4Wl4Ery7pWURQj7YY__m84z9FcVrgo8IxuJ94phQUmJKyxwyWopnxT4lkpU1a-jzh3VDqdwrDlO6wTjzDSdSvCz2WF1RzKjcL35cwhhDWoEZ3R2gudf9fXIJBYuOV66DwYU-LO9n6NKlr-hEmzHENEPad-hiGk0YYMOegu7Ha7TQEcq5uZ1chG4dtXoFHobyErLoqP2IPvfQJgd9r9HKwzQE7zSgj1kYYr5NI-eRRotr5yEBuoI4Oh3v0Wmu0Y26nyGKCf757Xue5KvihdV9gsOH-aD4cnJ8tTgtzy8-nS3m56WpsRhLWTNNrDW8sRUYoaVhVEggWreMssY0lnKguGMdZ4BtKxgxsu4aTepaMivZQXG21e2CvlGr6IZckgraqc1GiEulc52mB0WZNk1baUyx4C3hTQsUCLcCg-CW06z1Yau1mtoBOgN-jLrfEd098e5aLcOdkpJWdSWywLsHgRhuJ0ijGlwy6wf1EKakqKh4U0le1xl9-xd6E6aYvzhTTS0IqyUnT9RS5wactyHfa9aiai6YwDWvCM_U0T-oPNYeMcGDdXl_J4FuE0z2V4pgH3skWK0trLYWVtnCamNhtW7uzZ-v85jy27AZYFsg5SO_hPjU0n9kfwHga_zV</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>Li, Meng</creator><creator>Yang, Shanshan</creator><creator>Yao, Hongwu</creator><creator>Liu, Yunxi</creator><creator>Du, Mingmei</creator><general>Springer Healthcare</general><general>Springer</general><general>Springer Nature B.V</general><general>Adis, Springer Healthcare</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-3768-2821</orcidid></search><sort><creationdate>20230201</creationdate><title>Retrospective Analysis of Epidemiology, Risk Factors, and Outcomes of Health Care-Acquired Carbapenem-Resistant Klebsiella pneumoniae Bacteremia in a Chinese Tertiary Hospital, 2010–2019</title><author>Li, Meng ; Yang, Shanshan ; Yao, Hongwu ; Liu, Yunxi ; Du, Mingmei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c607t-963a1ffc48f5ec7a9c3279e1aab3238c8f24e20d3d43e0fb731c96d8a16693f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antibiotics</topic><topic>Carbapenem-resistant Klebsiella pneumoniae</topic><topic>Catheters</topic><topic>Epidemiology</topic><topic>Health aspects</topic><topic>Health care</topic><topic>Hospitals</topic><topic>Imipenem</topic><topic>Infectious Diseases</topic><topic>Internal Medicine</topic><topic>Medical instruments</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mortality</topic><topic>Original Research</topic><topic>Pancreatitis</topic><topic>Regression analysis</topic><topic>Resistance rate</topic><topic>Respiratory diseases</topic><topic>Respiratory tract diseases</topic><topic>Risk factors</topic><topic>Ventilation</topic><topic>Ventilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Meng</creatorcontrib><creatorcontrib>Yang, Shanshan</creatorcontrib><creatorcontrib>Yao, Hongwu</creatorcontrib><creatorcontrib>Liu, Yunxi</creatorcontrib><creatorcontrib>Du, Mingmei</creatorcontrib><collection>SpringerOpen</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Infectious diseases and therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Meng</au><au>Yang, Shanshan</au><au>Yao, Hongwu</au><au>Liu, Yunxi</au><au>Du, Mingmei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retrospective Analysis of Epidemiology, Risk Factors, and Outcomes of Health Care-Acquired Carbapenem-Resistant Klebsiella pneumoniae Bacteremia in a Chinese Tertiary Hospital, 2010–2019</atitle><jtitle>Infectious diseases and therapy</jtitle><stitle>Infect Dis Ther</stitle><addtitle>Infect Dis Ther</addtitle><date>2023-02-01</date><risdate>2023</risdate><volume>12</volume><issue>2</issue><spage>473</spage><epage>485</epage><pages>473-485</pages><issn>2193-8229</issn><eissn>2193-6382</eissn><abstract>Introduction
In the present study, we aimed to describe the proportion of carbapenem-resistant
Klebsiella pneumoniae
bloodstream infection (CRKP-BSI) in KP-BSI in one Chinese tertiary hospital over 10 years and determine the risk factors and outcomes of CRKP-BSI.
Methods
We retrospectively analyzed clinical and microbiological data of patients with KP-BSI from January 2010 to December 2019 to identify risk factors, clinical features, and outcomes using multivariate logistic regression analysis. KP-BSI only included monomicrobial BSI and health care-acquired BSI.
Results
Among the total 687 isolates of KP-BSI in this study, the rate of CRKP was 39.0% (268/687); this rate in the intensive care unit (ICU) was 65.6% and that in seven high-risk departments (including four ICUs, respiratory medicine, gastroenterology medicine, and hepatobiliary surgery) was 74.6%. The annual rate of CRKP in KP-BSI ranged from 0.0% in 2010 to 54.5% in 2019. The 28-day mortality was 36.2% in patients with CRKP-BSI and 11.7% in those with carbapenem-susceptible
K. pneumoniae
(CSKP) BSI. Multivariable logistic regression analysis showed that prior ICU stay (odds ratio [OR] 2.485,
P
< 0.001), hospital stay ≥ 30 days prior to BSI (OR 1.815,
P
= 0.007), prior mechanical ventilation (OR 2.020,
P
= 0.014), prior urinary catheter (OR 1.999,
P
= 0.003), prior carbapenem use (OR 3.840,
P
< 0.001), hepatobiliary disease (OR 2.943,
P
< 0.001), pancreatitis (OR 2.700,
P
= 0.026), and respiratory disease (OR 2.493,
P
= 0.009) were risk factors of CRKP-BSI. Patients with a first admission (OR 0.662,
P
= 0.046) had a lower percentage of CRKP-BSI.
Conclusion
The rapidly rising rate of CRKP-BSI in KP with high mortality requires increased attention. Exposure to carbapenems, ICU stay, invasive mechanical ventilation or urinary catheter, prolonged hospital stay, hepatobiliary disease, pancreatitis, and respiratory disease were found to be risk factors for CRKP-BSI. Strict control measures should be implemented to prevent the emergence and spread of CRKP, especially in high-risk departments.</abstract><cop>Cheshire</cop><pub>Springer Healthcare</pub><pmid>36520329</pmid><doi>10.1007/s40121-022-00732-7</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-3768-2821</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Infectious diseases and therapy, 2023-02, Vol.12 (2), p.473-485 |
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| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_23ac8b5a02074b148be2e14f70e74f42 |
| source | Publicly Available Content Database; Springer Nature - SpringerLink Journals - Fully Open Access ; PubMed Central; Alma/SFX Local Collection |
| subjects | Antibiotics Carbapenem-resistant Klebsiella pneumoniae Catheters Epidemiology Health aspects Health care Hospitals Imipenem Infectious Diseases Internal Medicine Medical instruments Medicine Medicine & Public Health Mortality Original Research Pancreatitis Regression analysis Resistance rate Respiratory diseases Respiratory tract diseases Risk factors Ventilation Ventilators |
| title | Retrospective Analysis of Epidemiology, Risk Factors, and Outcomes of Health Care-Acquired Carbapenem-Resistant Klebsiella pneumoniae Bacteremia in a Chinese Tertiary Hospital, 2010–2019 |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T01%3A21%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Retrospective%20Analysis%20of%20Epidemiology,%20Risk%20Factors,%20and%20Outcomes%20of%20Health%20Care-Acquired%20Carbapenem-Resistant%20Klebsiella%20pneumoniae%20Bacteremia%20in%20a%20Chinese%20Tertiary%20Hospital,%202010%E2%80%932019&rft.jtitle=Infectious%20diseases%20and%20therapy&rft.au=Li,%20Meng&rft.date=2023-02-01&rft.volume=12&rft.issue=2&rft.spage=473&rft.epage=485&rft.pages=473-485&rft.issn=2193-8229&rft.eissn=2193-6382&rft_id=info:doi/10.1007/s40121-022-00732-7&rft_dat=%3Cgale_doaj_%3EA737064514%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c607t-963a1ffc48f5ec7a9c3279e1aab3238c8f24e20d3d43e0fb731c96d8a16693f93%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2867136941&rft_id=info:pmid/36520329&rft_galeid=A737064514&rfr_iscdi=true |