Brain aging in temporal lobe epilepsy: Chronological, structural, and functional

• Published in: NeuroImage clinical 2020-01, Vol.25, p.102183, Article 102183
• Main Authors: Hwang, Gyujoon, Hermann, Bruce, Nair, Veena A., Conant, Lisa L., Dabbs, Kevin, Mathis, Jed, Cook, Cole J., Rivera-Bonet, Charlene N., Mohanty, Rosaleena, Zhao, Gengyan, Almane, Dace N., Nencka, Andrew, Felton, Elizabeth, Struck, Aaron F., Birn, Rasmus, Maganti, Rama, Humphries, Colin J., Raghavan, Manoj, DeYoe, Edgar A., Bendlin, Barbara B., Prabhakaran, Vivek, Binder, Jeffrey R., Meyerand, Mary E.
• Format: Article
• Language: English
• Subjects: Accelerated brain aging; Adult; Age Factors; Age prediction; Aging, Premature - diagnostic imaging; Aging, Premature - etiology; Aging, Premature - pathology; Aging, Premature - physiopathology; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - pathology; Cerebral Cortex - physiopathology; Cognitive aging; Cognitive Aging - physiology; Cognitive Dysfunction - diagnostic imaging; Cognitive Dysfunction - etiology; Cognitive Dysfunction - pathology; Cognitive Dysfunction - physiopathology; Connectome - methods; Epilepsy, Temporal Lobe - complications; Epilepsy, Temporal Lobe - diagnostic imaging; Epilepsy, Temporal Lobe - pathology; Epilepsy, Temporal Lobe - physiopathology; Female; Functional connectivity; Humans; Magnetic Resonance Imaging; Male; Medicin och hälsovetenskap; Middle Aged; Regular; Support Vector Machine; Temporal lobe epilepsy (TLE); Young Adult
• ISSN: 2213-1582; 2213-1582
• DOI: 10.1016/j.nicl.2020.102183

•TLE patients have older brain ages both functionally and structurally.•Functional brain age is a better predictor of cognitive abilites in TLE patients.•Weaker bilateral frontal/temporal connections affect functional brain aging in TLE.•Functional age mediates some of chronological age-fluid cognition relationships.•Accelerated brain aging in TLE affected by both seizure burden and polytherapy. The association of epilepsy with structural brain changes and cognitive abnormalities in midlife has raised concern regarding the possibility of future accelerated brain and cognitive aging and increased risk of later life neurocognitive disorders. To address this issue we examined age-related processes in both structural and functional neuroimaging among individuals with temporal lobe epilepsy (TLE, N = 104) who were participants in the Epilepsy Connectome Project (ECP). Support vector regression (SVR) models were trained from 151 healthy controls and used to predict TLE patients’ brain ages. It was found that TLE patients on average have both older structural (+6.6 years) and functional (+8.3 years) brain ages compared to healthy controls. Accelerated functional brain age (functional – chronological age) was mildly correlated (corrected P = 0.07) with complex partial seizure frequency and the number of anti-epileptic drug intake. Functional brain age was a significant correlate of declining cognition (fluid abilities) and partially mediated chronological age-fluid cognition relationships. Chronological age was the only positive predictor of crystallized cognition. Accelerated aging is evident not only in the structural brains of patients with TLE, but also in their functional brains. Understanding the causes of accelerated brain aging in TLE will be clinically important in order to potentially prevent or mitigate their cognitive deficits.