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Cardiac Fibrosis and Cardiac Fibroblast Lineage-Tracing: Recent Advances
Cardiac fibrosis is a common pathological change associated with cardiac injuries and diseases. Even though the accumulation of collagens and other extracellular matrix (ECM) proteins may have some protective effects in certain situations, prolonged fibrosis usually negatively affects cardiac functi...
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Published in: | Frontiers in physiology 2020-05, Vol.11, p.416-416 |
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description | Cardiac fibrosis is a common pathological change associated with cardiac injuries and diseases. Even though the accumulation of collagens and other extracellular matrix (ECM) proteins may have some protective effects in certain situations, prolonged fibrosis usually negatively affects cardiac function and often leads to deleterious consequences. While the development of cardiac fibrosis involves several cell types, the major source of ECM proteins is cardiac fibroblast. The high plasticity of cardiac fibroblasts enables them to quickly change their behaviors in response to injury and transition between several differentiation states. However, the study of cardiac fibroblasts
was very difficult due to the lack of specific research tools. The development of cardiac fibroblast lineage-tracing mouse lines has greatly promoted cardiac fibrosis research. In this article, we review the recent cardiac fibroblast lineage-tracing studies exploring the origin of cardiac fibroblasts and their complicated roles in cardiac fibrosis, and briefly discuss the translational potential of basic cardiac fibroblast researches. |
doi_str_mv | 10.3389/fphys.2020.00416 |
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was very difficult due to the lack of specific research tools. The development of cardiac fibroblast lineage-tracing mouse lines has greatly promoted cardiac fibrosis research. In this article, we review the recent cardiac fibroblast lineage-tracing studies exploring the origin of cardiac fibroblasts and their complicated roles in cardiac fibrosis, and briefly discuss the translational potential of basic cardiac fibroblast researches.</description><identifier>ISSN: 1664-042X</identifier><identifier>EISSN: 1664-042X</identifier><identifier>DOI: 10.3389/fphys.2020.00416</identifier><identifier>PMID: 32435205</identifier><language>eng</language><publisher>Switzerland: Frontiers Media S.A</publisher><subject>cardiac disease ; cardiac fibroblast ; fibrosis ; heart ; lineage-tracing ; Physiology</subject><ispartof>Frontiers in physiology, 2020-05, Vol.11, p.416-416</ispartof><rights>Copyright © 2020 Fu, Liu, Li, Li and Wang.</rights><rights>Copyright © 2020 Fu, Liu, Li, Li and Wang. 2020 Fu, Liu, Li, Li and Wang</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-962c2e2ab44c71c8ea34e8ad3f6fd264233b5ed135d64432381cf0fc5613a1443</citedby><cites>FETCH-LOGICAL-c528t-962c2e2ab44c71c8ea34e8ad3f6fd264233b5ed135d64432381cf0fc5613a1443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218116/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218116/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32435205$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fu, Xing</creatorcontrib><creatorcontrib>Liu, Qianglin</creatorcontrib><creatorcontrib>Li, Chaoyang</creatorcontrib><creatorcontrib>Li, Yuxia</creatorcontrib><creatorcontrib>Wang, Leshan</creatorcontrib><title>Cardiac Fibrosis and Cardiac Fibroblast Lineage-Tracing: Recent Advances</title><title>Frontiers in physiology</title><addtitle>Front Physiol</addtitle><description>Cardiac fibrosis is a common pathological change associated with cardiac injuries and diseases. Even though the accumulation of collagens and other extracellular matrix (ECM) proteins may have some protective effects in certain situations, prolonged fibrosis usually negatively affects cardiac function and often leads to deleterious consequences. While the development of cardiac fibrosis involves several cell types, the major source of ECM proteins is cardiac fibroblast. The high plasticity of cardiac fibroblasts enables them to quickly change their behaviors in response to injury and transition between several differentiation states. However, the study of cardiac fibroblasts
was very difficult due to the lack of specific research tools. The development of cardiac fibroblast lineage-tracing mouse lines has greatly promoted cardiac fibrosis research. In this article, we review the recent cardiac fibroblast lineage-tracing studies exploring the origin of cardiac fibroblasts and their complicated roles in cardiac fibrosis, and briefly discuss the translational potential of basic cardiac fibroblast researches.</description><subject>cardiac disease</subject><subject>cardiac fibroblast</subject><subject>fibrosis</subject><subject>heart</subject><subject>lineage-tracing</subject><subject>Physiology</subject><issn>1664-042X</issn><issn>1664-042X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkc1rGzEQxUVpaYKbe05lj72so-_IPRSCiZOAIVBSyE3MSiNbYb3rSuuA__vIHwmxLhJPb34z0iPkktGxEGZyFdbLbR5zyumYUsn0F3LOtJY1lfz566fzGbnI-YWWJYuXsu_kTHApFKfqnNxPIfkIrprFJvU55go6X52ITQt5qOaxQ1hg_ZTAxW7xu_qLDruhuvGv0DnMP8i3AG3Gi-M-Iv9mt0_T-3r-ePcwvZnXTnEz1BPNHUcOjZTumjmDICQa8CLo4LmWXIhGoWdCeS2l4MIwF2hwSjMBrCgj8nDg-h5e7DrFFaSt7SHavdCnhYU0RNei5XKCOijaGG-k5GFiSksPqBspXGOwsP4cWOtNs0K_e0-C9gR6etPFpV30r_aaM8OYLoBfR0Dq_28wD3YVs8O2hQ77TS4TUCWE5ooWKz1YXfnmnDB8tGHU7vK0-zztLk-7z7OU_Pw83kfBe3riDepDnDk</recordid><startdate>20200506</startdate><enddate>20200506</enddate><creator>Fu, Xing</creator><creator>Liu, Qianglin</creator><creator>Li, Chaoyang</creator><creator>Li, Yuxia</creator><creator>Wang, Leshan</creator><general>Frontiers Media S.A</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20200506</creationdate><title>Cardiac Fibrosis and Cardiac Fibroblast Lineage-Tracing: Recent Advances</title><author>Fu, Xing ; Liu, Qianglin ; Li, Chaoyang ; Li, Yuxia ; Wang, Leshan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-962c2e2ab44c71c8ea34e8ad3f6fd264233b5ed135d64432381cf0fc5613a1443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>cardiac disease</topic><topic>cardiac fibroblast</topic><topic>fibrosis</topic><topic>heart</topic><topic>lineage-tracing</topic><topic>Physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fu, Xing</creatorcontrib><creatorcontrib>Liu, Qianglin</creatorcontrib><creatorcontrib>Li, Chaoyang</creatorcontrib><creatorcontrib>Li, Yuxia</creatorcontrib><creatorcontrib>Wang, Leshan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Open Access: DOAJ - Directory of Open Access Journals</collection><jtitle>Frontiers in physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fu, Xing</au><au>Liu, Qianglin</au><au>Li, Chaoyang</au><au>Li, Yuxia</au><au>Wang, Leshan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiac Fibrosis and Cardiac Fibroblast Lineage-Tracing: Recent Advances</atitle><jtitle>Frontiers in physiology</jtitle><addtitle>Front Physiol</addtitle><date>2020-05-06</date><risdate>2020</risdate><volume>11</volume><spage>416</spage><epage>416</epage><pages>416-416</pages><issn>1664-042X</issn><eissn>1664-042X</eissn><abstract>Cardiac fibrosis is a common pathological change associated with cardiac injuries and diseases. Even though the accumulation of collagens and other extracellular matrix (ECM) proteins may have some protective effects in certain situations, prolonged fibrosis usually negatively affects cardiac function and often leads to deleterious consequences. While the development of cardiac fibrosis involves several cell types, the major source of ECM proteins is cardiac fibroblast. The high plasticity of cardiac fibroblasts enables them to quickly change their behaviors in response to injury and transition between several differentiation states. However, the study of cardiac fibroblasts
was very difficult due to the lack of specific research tools. The development of cardiac fibroblast lineage-tracing mouse lines has greatly promoted cardiac fibrosis research. In this article, we review the recent cardiac fibroblast lineage-tracing studies exploring the origin of cardiac fibroblasts and their complicated roles in cardiac fibrosis, and briefly discuss the translational potential of basic cardiac fibroblast researches.</abstract><cop>Switzerland</cop><pub>Frontiers Media S.A</pub><pmid>32435205</pmid><doi>10.3389/fphys.2020.00416</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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subjects | cardiac disease cardiac fibroblast fibrosis heart lineage-tracing Physiology |
title | Cardiac Fibrosis and Cardiac Fibroblast Lineage-Tracing: Recent Advances |
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