Effects of aerobic, resistance, and combined training on endothelial function and arterial stiffness in older adults: study protocol for a systematic review and meta-analysis

Introduction Aging is an independent risk factor for cardiovascular events. It promotes vascular dysfunction which is associated with risk factors for cardiovascular diseases (CVDs). Exercise can modulate vascular function parameters, but little is known about the effects of different modalities of...

Full description

Saved in:
Bibliographic Details
Published in:Systematic reviews 2022-08, Vol.11 (1), p.1-171, Article 171
Main Authors: da Silva, Raphael S. N., da Silva, Diego S., Waclawovsky, Gustavo, Schaun, Maximiliano I.
Format: Article
Language:English
Subjects:
Aerobics
Aging
Alzheimer's disease
Clinical trials
Endothelium
Exercise
Fitness training programs
Hypertension
Intervention
Meta-analysis
Middle age
Mortality
Older people
Physical fitness
Protocol
Pulse wave analysis
Reactive hyperemia
Risk factors
Strength training
Systematic review
Vascular stiffness
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction Aging is an independent risk factor for cardiovascular events. It promotes vascular dysfunction which is associated with risk factors for cardiovascular diseases (CVDs). Exercise can modulate vascular function parameters, but little is known about the effects of different modalities of training (aerobic, resistance, and combined) on endothelial function and arterial stiffness in older adults. Methods This systematic review study will include randomized controlled trials (RCTs) selected from the electronic databases MEDLINE (PubMed), Cochrane, LILACS, EMBASE, and Web of Science. We will follow the PRISMA guidelines and PICOS framework. Studies involving both male and female older adults (≥60 years old) with or without comorbidities undergoing aerobic, resistance, and/or combined training compared to a control group (no exercise) will be eligible. We will use the Cochrane Risk of Bias 2 (RoB 2) tool to evaluate the quality of individual studies and GRADE to assess the strength of evidence. Statistical analyses will be conducted with RStudio for Windows (v1.3.959) using R package meta. Discussion A systematic review and meta-analysis involving data from studies of older adults would deepen our understanding of vascular adaptations to exercise training in this population. It could provide new insights into how health providers can improve patient management and prevention of cardiovascular events in older adults. Systematic review registration PROSPERO 42021275451
ISSN:2046-4053
2046-4053
DOI:10.1186/s13643-022-02036-w