Emerging advances in identifying signal transmission molecules involved in the interaction between Mycobacterium tuberculosis and the host

Tuberculosis caused by Mycobacterium tuberculosis (MTB) is an ancient chronic infectious disease and is still the leading cause of death worldwide due to a single infectious disease. MTB can achieve immune escape by interacting with host cells through its special cell structure and secreting a varie...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in cellular and infection microbiology 2022-07, Vol.12, p.956311-956311
Main Authors: Wang, Yue, Shi, Qiyuan, Chen, Qi, Zhou, Xuebin, Yuan, Huiling, Jia, Xiwen, Liu, Shuyuan, Li, Qin, Ge, Lijun
Format: Article
Language:English
Subjects:
Cellular and Infection Microbiology
chronic infectious disease
immune escape
innate immunity
Mycobacterium tuberculosis
signaling pathway
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c442t-71ad67b231d1caef0374cc3165f810781494fbcfe3733420aeaf08c184e0e753
cites cdi_FETCH-LOGICAL-c442t-71ad67b231d1caef0374cc3165f810781494fbcfe3733420aeaf08c184e0e753
container_end_page 956311
container_issue
container_start_page 956311
container_title Frontiers in cellular and infection microbiology
container_volume 12
creator Wang, Yue
Shi, Qiyuan
Chen, Qi
Zhou, Xuebin
Yuan, Huiling
Jia, Xiwen
Liu, Shuyuan
Li, Qin
Ge, Lijun
description Tuberculosis caused by Mycobacterium tuberculosis (MTB) is an ancient chronic infectious disease and is still the leading cause of death worldwide due to a single infectious disease. MTB can achieve immune escape by interacting with host cells through its special cell structure and secreting a variety of effector proteins. Innate immunity-related pattern recognition receptors (PPR receptors) play a key role in the regulation of signaling pathways. In this review, we focus on the latest research progress on related signal transduction molecules in the interaction between MTB and the host. In addition, we provide new research ideas for the development of new anti-tuberculosis drug targets and lead compounds and provide an overview of information useful for approaching future tuberculosis host-oriented treatment research approaches and strategies, which has crucial scientific guiding significance and research value.
doi_str_mv 10.3389/fcimb.2022.956311
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_267335aefb8f4a1d81374aa576223a36</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_267335aefb8f4a1d81374aa576223a36</doaj_id><sourcerecordid>2702177824</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-71ad67b231d1caef0374cc3165f810781494fbcfe3733420aeaf08c184e0e753</originalsourceid><addsrcrecordid>eNpVks9q3DAQxk1paEKaB8jNx152q3-25EughLQNpPSSuxjLI6-CLSWSvGVfoU8deTeURpcRM9_8Bma-qrqmZMu56r5a4-Z-ywhj265pOaUfqgvGeLNhnVIf__ufV1cpPZHyJGGq45-qc950Tceluqj-3s0YR-fHGoY9eIOpdr52A_rs7GHNJzd6mOocwafZpeSCr-cwoVmmo3gfpj0Oa1feYQkZI5i8qnrMfxB9_etgQl9yGN0y13npMZbmkFyqwQ_Htl1I-XN1ZmFKePUWL6vH73ePtz83D79_3N9-e9gYIVjeSApDK3vG6UANoCVcCmM4bRurKJGKik7Y3ljkknPBCCBYogxVAgnKhl9W9yfsEOBJP0c3QzzoAE4fEyGOGmJ2ZkLN2oJoyoxeWQF0ULTMAmhkW5YLvC2smxPreelnHEzZWoTpHfR9xbudHsNed-UCohUF8OUNEMPLginrsmKD0wQew5I0KyejUiq2SulJamJIKaL9N4YSvTpCHx2hV0fokyP4KwSyrQ8</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2702177824</pqid></control><display><type>article</type><title>Emerging advances in identifying signal transmission molecules involved in the interaction between Mycobacterium tuberculosis and the host</title><source>PubMed Central</source><creator>Wang, Yue ; Shi, Qiyuan ; Chen, Qi ; Zhou, Xuebin ; Yuan, Huiling ; Jia, Xiwen ; Liu, Shuyuan ; Li, Qin ; Ge, Lijun</creator><creatorcontrib>Wang, Yue ; Shi, Qiyuan ; Chen, Qi ; Zhou, Xuebin ; Yuan, Huiling ; Jia, Xiwen ; Liu, Shuyuan ; Li, Qin ; Ge, Lijun</creatorcontrib><description>Tuberculosis caused by Mycobacterium tuberculosis (MTB) is an ancient chronic infectious disease and is still the leading cause of death worldwide due to a single infectious disease. MTB can achieve immune escape by interacting with host cells through its special cell structure and secreting a variety of effector proteins. Innate immunity-related pattern recognition receptors (PPR receptors) play a key role in the regulation of signaling pathways. In this review, we focus on the latest research progress on related signal transduction molecules in the interaction between MTB and the host. In addition, we provide new research ideas for the development of new anti-tuberculosis drug targets and lead compounds and provide an overview of information useful for approaching future tuberculosis host-oriented treatment research approaches and strategies, which has crucial scientific guiding significance and research value.</description><identifier>ISSN: 2235-2988</identifier><identifier>EISSN: 2235-2988</identifier><identifier>DOI: 10.3389/fcimb.2022.956311</identifier><identifier>PMID: 35959378</identifier><language>eng</language><publisher>Frontiers Media S.A</publisher><subject>Cellular and Infection Microbiology ; chronic infectious disease ; immune escape ; innate immunity ; Mycobacterium tuberculosis ; signaling pathway</subject><ispartof>Frontiers in cellular and infection microbiology, 2022-07, Vol.12, p.956311-956311</ispartof><rights>Copyright © 2022 Wang, Shi, Chen, Zhou, Yuan, Jia, Liu, Li and Ge 2022 Wang, Shi, Chen, Zhou, Yuan, Jia, Liu, Li and Ge</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-71ad67b231d1caef0374cc3165f810781494fbcfe3733420aeaf08c184e0e753</citedby><cites>FETCH-LOGICAL-c442t-71ad67b231d1caef0374cc3165f810781494fbcfe3733420aeaf08c184e0e753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359464/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359464/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Wang, Yue</creatorcontrib><creatorcontrib>Shi, Qiyuan</creatorcontrib><creatorcontrib>Chen, Qi</creatorcontrib><creatorcontrib>Zhou, Xuebin</creatorcontrib><creatorcontrib>Yuan, Huiling</creatorcontrib><creatorcontrib>Jia, Xiwen</creatorcontrib><creatorcontrib>Liu, Shuyuan</creatorcontrib><creatorcontrib>Li, Qin</creatorcontrib><creatorcontrib>Ge, Lijun</creatorcontrib><title>Emerging advances in identifying signal transmission molecules involved in the interaction between Mycobacterium tuberculosis and the host</title><title>Frontiers in cellular and infection microbiology</title><description>Tuberculosis caused by Mycobacterium tuberculosis (MTB) is an ancient chronic infectious disease and is still the leading cause of death worldwide due to a single infectious disease. MTB can achieve immune escape by interacting with host cells through its special cell structure and secreting a variety of effector proteins. Innate immunity-related pattern recognition receptors (PPR receptors) play a key role in the regulation of signaling pathways. In this review, we focus on the latest research progress on related signal transduction molecules in the interaction between MTB and the host. In addition, we provide new research ideas for the development of new anti-tuberculosis drug targets and lead compounds and provide an overview of information useful for approaching future tuberculosis host-oriented treatment research approaches and strategies, which has crucial scientific guiding significance and research value.</description><subject>Cellular and Infection Microbiology</subject><subject>chronic infectious disease</subject><subject>immune escape</subject><subject>innate immunity</subject><subject>Mycobacterium tuberculosis</subject><subject>signaling pathway</subject><issn>2235-2988</issn><issn>2235-2988</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVks9q3DAQxk1paEKaB8jNx152q3-25EughLQNpPSSuxjLI6-CLSWSvGVfoU8deTeURpcRM9_8Bma-qrqmZMu56r5a4-Z-ywhj265pOaUfqgvGeLNhnVIf__ufV1cpPZHyJGGq45-qc950Tceluqj-3s0YR-fHGoY9eIOpdr52A_rs7GHNJzd6mOocwafZpeSCr-cwoVmmo3gfpj0Oa1feYQkZI5i8qnrMfxB9_etgQl9yGN0y13npMZbmkFyqwQ_Htl1I-XN1ZmFKePUWL6vH73ePtz83D79_3N9-e9gYIVjeSApDK3vG6UANoCVcCmM4bRurKJGKik7Y3ljkknPBCCBYogxVAgnKhl9W9yfsEOBJP0c3QzzoAE4fEyGOGmJ2ZkLN2oJoyoxeWQF0ULTMAmhkW5YLvC2smxPreelnHEzZWoTpHfR9xbudHsNed-UCohUF8OUNEMPLginrsmKD0wQew5I0KyejUiq2SulJamJIKaL9N4YSvTpCHx2hV0fokyP4KwSyrQ8</recordid><startdate>20220725</startdate><enddate>20220725</enddate><creator>Wang, Yue</creator><creator>Shi, Qiyuan</creator><creator>Chen, Qi</creator><creator>Zhou, Xuebin</creator><creator>Yuan, Huiling</creator><creator>Jia, Xiwen</creator><creator>Liu, Shuyuan</creator><creator>Li, Qin</creator><creator>Ge, Lijun</creator><general>Frontiers Media S.A</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20220725</creationdate><title>Emerging advances in identifying signal transmission molecules involved in the interaction between Mycobacterium tuberculosis and the host</title><author>Wang, Yue ; Shi, Qiyuan ; Chen, Qi ; Zhou, Xuebin ; Yuan, Huiling ; Jia, Xiwen ; Liu, Shuyuan ; Li, Qin ; Ge, Lijun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-71ad67b231d1caef0374cc3165f810781494fbcfe3733420aeaf08c184e0e753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cellular and Infection Microbiology</topic><topic>chronic infectious disease</topic><topic>immune escape</topic><topic>innate immunity</topic><topic>Mycobacterium tuberculosis</topic><topic>signaling pathway</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yue</creatorcontrib><creatorcontrib>Shi, Qiyuan</creatorcontrib><creatorcontrib>Chen, Qi</creatorcontrib><creatorcontrib>Zhou, Xuebin</creatorcontrib><creatorcontrib>Yuan, Huiling</creatorcontrib><creatorcontrib>Jia, Xiwen</creatorcontrib><creatorcontrib>Liu, Shuyuan</creatorcontrib><creatorcontrib>Li, Qin</creatorcontrib><creatorcontrib>Ge, Lijun</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Frontiers in cellular and infection microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yue</au><au>Shi, Qiyuan</au><au>Chen, Qi</au><au>Zhou, Xuebin</au><au>Yuan, Huiling</au><au>Jia, Xiwen</au><au>Liu, Shuyuan</au><au>Li, Qin</au><au>Ge, Lijun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Emerging advances in identifying signal transmission molecules involved in the interaction between Mycobacterium tuberculosis and the host</atitle><jtitle>Frontiers in cellular and infection microbiology</jtitle><date>2022-07-25</date><risdate>2022</risdate><volume>12</volume><spage>956311</spage><epage>956311</epage><pages>956311-956311</pages><issn>2235-2988</issn><eissn>2235-2988</eissn><abstract>Tuberculosis caused by Mycobacterium tuberculosis (MTB) is an ancient chronic infectious disease and is still the leading cause of death worldwide due to a single infectious disease. MTB can achieve immune escape by interacting with host cells through its special cell structure and secreting a variety of effector proteins. Innate immunity-related pattern recognition receptors (PPR receptors) play a key role in the regulation of signaling pathways. In this review, we focus on the latest research progress on related signal transduction molecules in the interaction between MTB and the host. In addition, we provide new research ideas for the development of new anti-tuberculosis drug targets and lead compounds and provide an overview of information useful for approaching future tuberculosis host-oriented treatment research approaches and strategies, which has crucial scientific guiding significance and research value.</abstract><pub>Frontiers Media S.A</pub><pmid>35959378</pmid><doi>10.3389/fcimb.2022.956311</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2235-2988
ispartof Frontiers in cellular and infection microbiology, 2022-07, Vol.12, p.956311-956311
issn 2235-2988
2235-2988
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_267335aefb8f4a1d81374aa576223a36
source PubMed Central
subjects Cellular and Infection Microbiology
chronic infectious disease
immune escape
innate immunity
Mycobacterium tuberculosis
signaling pathway
title Emerging advances in identifying signal transmission molecules involved in the interaction between Mycobacterium tuberculosis and the host
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T01%3A25%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Emerging%20advances%20in%20identifying%20signal%20transmission%20molecules%20involved%20in%20the%20interaction%20between%20Mycobacterium%20tuberculosis%20and%20the%20host&rft.jtitle=Frontiers%20in%20cellular%20and%20infection%20microbiology&rft.au=Wang,%20Yue&rft.date=2022-07-25&rft.volume=12&rft.spage=956311&rft.epage=956311&rft.pages=956311-956311&rft.issn=2235-2988&rft.eissn=2235-2988&rft_id=info:doi/10.3389/fcimb.2022.956311&rft_dat=%3Cproquest_doaj_%3E2702177824%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c442t-71ad67b231d1caef0374cc3165f810781494fbcfe3733420aeaf08c184e0e753%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2702177824&rft_id=info:pmid/35959378&rfr_iscdi=true