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Two-Photon-Induced [2 + 2] Cycloaddition of Bis-thymines: A Biocompatible and Reversible Approach

Despite having great value across a wide variety of scientific fields, two-photon polymerizations currently suffer from two significant problems: the need for photoinitiators, which generate toxic side products, and the irreversibility of the process. Hence, the design of a versatile approach that c...

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Published in:ACS omega 2020-05, Vol.5 (20), p.11547-11552
Main Authors: Ricci, Monica, Rutten, Martin G.T.A, Toyouchi, Shuichi, Nanayakkara, Sepa, Fortuni, Beatrice, Vitale, Raffaele, Rocha, Susana, Wilson, Daniela A, Hofkens, Johan, Saito, Kei, Uji-i, Hiroshi
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cited_by cdi_FETCH-LOGICAL-a586t-e2b4a6d3290c1e20f8c5f906f3e0ddd0b4683713db7a49de92e96fc329ae0bff3
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container_end_page 11552
container_issue 20
container_start_page 11547
container_title ACS omega
container_volume 5
creator Ricci, Monica
Rutten, Martin G.T.A
Toyouchi, Shuichi
Nanayakkara, Sepa
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Vitale, Raffaele
Rocha, Susana
Wilson, Daniela A
Hofkens, Johan
Saito, Kei
Uji-i, Hiroshi
description Despite having great value across a wide variety of scientific fields, two-photon polymerizations currently suffer from two significant problems: the need for photoinitiators, which generate toxic side products, and the irreversibility of the process. Hence, the design of a versatile approach that circumvents these issues represents a major scientific challenge. Herein, we report a two-photon absorption strategy where reversible [2 + 2] cycloaddition of bis-thymines was achieved without the need for any photoinitiator. The cycloaddition and cycloreversion reactions could be induced by simply changing the irradiation wavelength, and repeated writing and erasing cycles were performed. The simplicity, reversibility, and biocompatibility of this strategy open up a whole new toolbox for applications across a wide variety of scientific fields.
doi_str_mv 10.1021/acsomega.0c00770
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title Two-Photon-Induced [2 + 2] Cycloaddition of Bis-thymines: A Biocompatible and Reversible Approach
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