Early steroid withdrawal has a positive effect on bone in kidney transplant recipients: a propensity score study with inverse probability-of-treatment weighting

Background: Long-term corticosteroid use after kidney transplantation is associated with a decrease in bone mineral density (BMD) and a high fracture risk. We hypothesized that patients with early steroid withdrawal (ESW) would display a gain in BMD in the year following kidney transplantation, when...

Full description

Saved in:
Bibliographic Details
Published in:Therapeutic advances in musculoskeletal disease 2020, Vol.12, p.1759720X20953357
Main Authors: Batteux, Benjamin, Gras-Champel, Valérie, Lando, Mathilde, Brazier, François, Mentaverri, Romuald, Desailly-Henry, Isabelle, Rey, Amayelle, Bennis, Youssef, Masmoudi, Kamel, Choukroun, Gabriel, Liabeuf, Sophie
Format: Article
Language:English
Subjects:
Bone density
Clinical outcomes
Clinical trials
Drug dosages
Fractures
Kidney transplants
Life Sciences
Original Research
Osteoporosis
Risk factors
Steroids
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Long-term corticosteroid use after kidney transplantation is associated with a decrease in bone mineral density (BMD) and a high fracture risk. We hypothesized that patients with early steroid withdrawal (ESW) would display a gain in BMD in the year following kidney transplantation, when compared with patients on long-term corticosteroid therapy. Methods: In a cohort of kidney transplant recipients, 356 patients were included between 2012 and 2019. Dual-energy X-ray absorptiometry was performed 1 and 12 months after transplantation. The data were analyzed using linear regression with inverse probability-of-treatment weighting (based on a propensity score). Results: At 1 year after transplantation, the gain in BMD was significantly greater in recipients with ESW than in recipients on long-term corticosteroid therapy for the lumbar spine (+0.036 g/cm2, p 
ISSN:1759-720X
1759-7218
DOI:10.1177/1759720X20953357