Modulation of fat metabolism and gut microbiota by resveratrol on high-fat diet-induced obese mice

The antioxidant resveratrol (RSV) has low bioavailability and can reach the colon to access the gut microbial ecosystem. RSV administration together with high-fat diet prevented abnormal changes of intestinal microbiota. However, whether or not RSV can reshape the intestinal microbiota of obese mice...

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Bibliographic Details
Published in:Diabetes, metabolic syndrome and obesity metabolic syndrome and obesity, 2019-01, Vol.12, p.97-107
Main Authors: Campbell, C Linda, Yu, Renqiang, Li, Fengzhi, Zhou, Qin, Chen, Daozhen, Qi, Ce, Yin, Yongxiang, Sun, Jin
Format: Article
Language:English
Subjects:
Analysis
Antioxidants
Atherosclerosis
Bioavailability
Bioengineering
Body weight
Childrens health
Cholesterol
Colon
Cytokines
Diabetes
Diabetic retinopathy
Diet
Drinking water
Food science
gut microbiota
High fat diet
Hospitals
Hyperglycemia
Inflammation
Liver
Medical research
Medicine, Experimental
Metabolic syndrome
Metabolites
Microbiota
Microbiota (Symbiotic organisms)
Nutrition research
Obesity
Original Research
Oxidative stress
Physiological aspects
Polyphenols
Resveratrol
Tumor necrosis factor-TNF
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Summary:The antioxidant resveratrol (RSV) has low bioavailability and can reach the colon to access the gut microbial ecosystem. RSV administration together with high-fat diet prevented abnormal changes of intestinal microbiota. However, whether or not RSV can reshape the intestinal microbiota of obese mice and alleviate obesity-related diseases remains to be studied. This study aimed to explore the role of RSV in alleviating high-fat-induced obesity and its relationship with oxidative stress and gut microbiota. Male C57BL/6 mice were divided into five groups and administered for 16 weeks with: standard diet (CON), high-fat diet (60% energy for lard, HFD), and HFD with low, medium, and high dose of RSV, 50, 75, and 100 mg/kg body weight administered daily via drinking water, respectively. Medium and high RSV treatment significantly prevented body weight gain, decreased relative weight of liver and adipose tissue compared with HFD (
ISSN:1178-7007
1178-7007
DOI:10.2147/dmso.s192228