Impact of offspring endothelial function from de novo hypertensive disorders during pregnancy: An evidence-based review

De novo hypertensive disorders of pregnancy (HDP) which consist of gestational hypertension and preeclampsia affect maternal and offspring morbidity and mortality, and potentially increase the risk of cardiovascular disease in the offspring. It is well known that HDP causes various maternal complica...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in surgery 2022-11, Vol.9, p.967785
Main Authors: Abdull Sukor, Aslah Nabilah, Ankasha, Sheril June, Ugusman, Azizah, Aminuddin, Amilia, Mokhtar, Norfilza Mohd, Zainal Abidin, Shahidee, Ahmad, Mohd Faizal, Hamid, Adila A
Format: Article
Language:English
Subjects:
cardiovascular disease
endothelial function
hypertensive disorders of pregnancy
offspring
preeclampsia
Surgery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:De novo hypertensive disorders of pregnancy (HDP) which consist of gestational hypertension and preeclampsia affect maternal and offspring morbidity and mortality, and potentially increase the risk of cardiovascular disease in the offspring. It is well known that HDP causes various maternal complications, including cardiovascular diseases, placental abruption and liver and kidney failure. However, there are studies suggesting that offspring of pregnancies complicated by HDP have an increased risk of long-term cardiovascular disease. The endothelium is an important regulator of vascular function, and its dysfunction is highly associated with the development of cardiovascular diseases. Hence, this review aimed to systematically identify articles related to the effect of HDP on the endothelial function of the offspring. A computerized database search was conducted on PubMed, Scopus, and Medline from 1976 until 2022. A total of 685 articles were obtained. We identified another three additional articles through review articles and Google Scholar. Altogether, we used 13 articles for data extraction. All studies reported that endothelial function was impaired in the offspring of HDP. This is most likely attributed to impaired vasodilation, subclinical atherosclerosis formation, inflammation, and dysregulated epigenetic regulation of endothelial functions.
ISSN:2296-875X
2296-875X
DOI:10.3389/fsurg.2022.967785