What the BTBR/J mouse has taught us about diabetes and diabetic complications

Human and mouse genetics have delivered numerous diabetogenic loci, but it is mainly through the use of animal models that the pathophysiological basis for their contribution to diabetes has been investigated. More than 20 years ago, we serendipidously identified a mouse strain that could serve as a...

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Bibliographic Details
Published in:iScience 2023-07, Vol.26 (7), p.107036-107036, Article 107036
Main Authors: Keller, Mark P., Hudkins, Kelly L., Shalev, Anath, Bhatnagar, Sushant, Kebede, Melkam A., Merrins, Matthew J., Davis, Dawn Belt, Alpers, Charles E., Kimple, Michelle E., Attie, Alan D.
Format: Article
Language:English
Subjects:
Animal physiology
Human metabolism
Model organism
Review
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Summary:Human and mouse genetics have delivered numerous diabetogenic loci, but it is mainly through the use of animal models that the pathophysiological basis for their contribution to diabetes has been investigated. More than 20 years ago, we serendipidously identified a mouse strain that could serve as a model of obesity-prone type 2 diabetes, the BTBR (Black and Tan Brachyury) mouse (BTBR T+ Itpr3tf/J, 2018) carrying the Lepob mutation. We went on to discover that the BTBR-Lepob mouse is an excellent model of diabetic nephropathy and is now widely used by nephrologists in academia and the pharmaceutical industry. In this review, we describe the motivation for developing this animal model, the many genes identified and the insights about diabetes and diabetes complications derived from >100 studies conducted in this remarkable animal model. [Display omitted] Animal physiology; Human metabolism; Model organism
ISSN:2589-0042
2589-0042
DOI:10.1016/j.isci.2023.107036