Off‐Hour Admission and Mortality Risk for 28 Specific Diseases: A Systematic Review and Meta‐Analysis of 251 Cohorts

Background A considerable amount of studies have examined the relationship between off‐hours (weekends and nights) admission and mortality risk for various diseases, but the results remain equivocal. Methods and Results Through a search of EMBASE, PUBMED, Web of Science, and Cochrane Database of Sys...

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Bibliographic Details
Published in:Journal of the American Heart Association 2016-03, Vol.5 (3), p.e003102-n/a
Main Authors: Zhou, Yanfeng, Li, Wenzhen, Herath, Chulani, Xia, Jiahong, Hu, Bo, Song, Fujian, Cao, Shiyi, Lu, Zuxun
Format: Article
Language:English
Subjects:
After-Hours Care
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - mortality
Cardiovascular Diseases - therapy
Cause of Death
Chi-Square Distribution
Communicable Diseases - diagnosis
Communicable Diseases - mortality
Communicable Diseases - therapy
disease
Gastrointestinal Diseases - diagnosis
Gastrointestinal Diseases - mortality
Gastrointestinal Diseases - therapy
Hospital Mortality
Humans
Kidney Diseases - diagnosis
Kidney Diseases - mortality
Kidney Diseases - therapy
meta‐analysis
mortality
Neoplasms - diagnosis
Neoplasms - mortality
Neoplasms - therapy
Odds Ratio
off‐hour
Original Research
Patient Admission
Prognosis
Regression Analysis
Respiratory Tract Diseases - diagnosis
Respiratory Tract Diseases - mortality
Respiratory Tract Diseases - therapy
Risk Assessment
Risk Factors
Time Factors
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Summary:Background A considerable amount of studies have examined the relationship between off‐hours (weekends and nights) admission and mortality risk for various diseases, but the results remain equivocal. Methods and Results Through a search of EMBASE, PUBMED, Web of Science, and Cochrane Database of Systematic Reviews, we identified cohort studies that evaluated the association between off‐hour admission and mortality risk for disease. In a random effects meta‐analysis of 140 identified articles (251 cohorts), off‐hour admission was strongly associated with increased mortality for aortic aneurysm (odds ratio, 1.52; 95% CI, 1.30–1.77), breast cancer (1.50, 1.21–1.86), leukemia (1.45, 1.17–1.79), respiratory neoplasm (1.32, 1.20–1.26), pancreatic cancer (1.32, 1.12–1.56), malignant neoplasm of genitourinary organs (1.27, 1.08–1.49), colorectal cancer (1.26, 1.07–1.49), pulmonary embolism (1.20, 1.13–1.28), arrhythmia and cardiac arrest (1.19, 1.09–1.29), and lymphoma (1.19, 1.06–1.34). Weaker (odds ratio
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.115.003102