The Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) versus Transcranial Direct-Current Stimulation (tDCS) on Migraine Headaches: A Randomized Clinical Trial

• Published in: Advanced biomedical research 2024, Vol.13 (1), p.7-7
• Main Authors: Naji, Fatemeh, Sharbafchi, Mohammad Reza, Khorvash, Fariborz, Maracy, Mohammad R, Ghasemi Mobarak Abadi, Niloofar
• Format: Article
• Language: English
• Subjects: Anxiety; Clinical trials; depression; Effectiveness; Headache; Headaches; Magnetic fields; Mental depression; Migraine; migraine headaches; Pain; Prefrontal cortex; repetitive transcranial magnetic stimulation; Statistical analysis; transcranial direct-current stimulation; Transcranial magnetic stimulation
• ISSN: 2277-9175; 2277-9175
• DOI: 10.4103/abr.abr_142_23

Non-pharmacologic prophylactic methods for chronic migraine have been developed, including the promising non-invasive techniques of repetitive transcranial magnetic stimulation (rTMS) and transcranial direct-current stimulation (tDCS). This study aimed to compare the efficacy of rTMS and tDCS on pain intensity, the impact of headaches on daily life, anxiety, and depression in migraine headaches patients. This randomized clinical trial was conducted on 72 patients with migraine headaches, randomly allocated to the rTMS and tDCS groups. Participants received 3 and 12 sessions of stimulation over the left dorsolateral prefrontal cortex (DLPFC), respectively. Follow-up measurements, including pain intensity, anxiety, depression, and impact on daily life, were performed one month after the last sessions. Analyses were done by IBM SPSS statistics version 26 software. Of 72 patients enrolled in the study, 19 were male (8 in the rTMS group and 11 in the tDCS group). There was no significant difference in baseline characteristics between groups. During the follow-up visit, both groups showed a decrease in anxiety levels ( values = 0.005 and 0.015), while only the rTMS group displayed a significant improvement in depression ( value = 0.01). However, no statistically significant difference was found among the groups regarding changes in pain intensity, anxiety, and the impact of headaches on daily life ( values >0.05). Our findings suggest that both rTMS and tDCS may be effective in reducing pain intensity and improving the impact of headaches on daily life and anxiety in patients with chronic migraine. However, significant improvement in depression was only observed in the rTMS group patients.