Response to letter regarding “Successful nutritional control of scratching and clinical signs associated with adverse food reaction: A randomized controlled COSCAD'18 adherent clinical trial in the United States” and “Successful nutritional control of scratching and clinical signs associated with adverse food reaction: A randomized controlled COSCAD'18 adherent clinical trial in the United Kingdom”

• Published in: Journal of veterinary internal medicine 2021-11, Vol.35 (6), p.2565-2566
• Main Authors: Weemhoff, James L., MacLeay, Jennifer M., Bredja, John, Schiefelbein, Heidi, Wernimont, Susan M., Gross, Kathy L.
• Format: Article
• Language: English
• Subjects: Allergens; Animals; Clinical trials; Dog Diseases; Dogs; Food; Letter to the Editor; Letters to the Editor; United Kingdom; United States
• ISSN: 0891-6640; 1939-1676
• DOI: 10.1111/jvim.16300

Dear Editors, We thank Drs. Olivry, Saridomichelakis and Santoro for their insightful comments regarding our papers in which the recommended outcome measures portion of the COSCAD'18 and other criteria were used to evaluate the efficacy of dietary interventions for dogs with adverse reactions to food (AFR). A recent publication confirms that an oral food challenge is likely to result in relapse of clinical signs of 50% of dogs by day 5, and by 90% or more of dogs by day 14, indicating that the 21-day observation period used in our studies was sufficient to allow for adequate time for clinical signs of relapse to occur. 6 The authors rechecked confidence interval (CI) calculations for CADLI and PVAS (95% CI are based on ± t[0.05] × SE) and we confirm that these dogs were indeed stable based on CADLI and PVAS scores. [...]our studies also provided data from a validated, objective measure of scratching behavior, from use of a wearable activity monitor and the results aligned well with results from CADLI and PVAS tools. 7 These works conform to CONSORT reporting guidelines and contain extensive supporting data.