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Gemella haemolysans inhibits the growth of the periodontal pathogen Porphyromonas gingivalis
The oral microbiome plays an important role in the human microbial community and in maintaining the health of an individual. Imbalances in the oral microbiome may contribute to oral and systemic diseases. The progression of periodontal disease is closely related to the growth of bacteria, such as Po...
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| Published in: | Scientific reports 2021-06, Vol.11 (1), p.11742-12, Article 11742 |
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| creator | Miyoshi, Tomohiro Oge, Shogo Nakata, Satoshi Ueno, Yuji Ukita, Hidehiko Kousaka, Reiko Miura, Yuki Yoshinari, Nobuo Yoshida, Akihiro |
| description | The oral microbiome plays an important role in the human microbial community and in maintaining the health of an individual. Imbalances in the oral microbiome may contribute to oral and systemic diseases. The progression of periodontal disease is closely related to the growth of bacteria, such as
Porphyromonas gingivalis
, in the oral cavity. However, the pathogen growth mechanism specific to periodontal disease remains unknown. This study aimed to identify bacteria associated with periodontal health by focusing on hemolytic bacteria. Unstimulated saliva samples were collected from ten periodontitis patients and five healthy subjects to detect and identify the presence of hemolytic bacteria. The saliva of healthy subjects contained a higher proportion of
G. haemolysans
than saliva samples from patients with periodontitis. Growth inhibition assays indicated that the protein components contained in the culture supernatant of
G. haemolysans
directly suppressed the growth of
P. gingivalis
. This study shows that the presence of
G. haemolysans
in saliva is associated with periodontal health and that it inhibits the growth of
P. gingivalis
in vitro. |
| doi_str_mv | 10.1038/s41598-021-91267-3 |
| format | article |
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Porphyromonas gingivalis
, in the oral cavity. However, the pathogen growth mechanism specific to periodontal disease remains unknown. This study aimed to identify bacteria associated with periodontal health by focusing on hemolytic bacteria. Unstimulated saliva samples were collected from ten periodontitis patients and five healthy subjects to detect and identify the presence of hemolytic bacteria. The saliva of healthy subjects contained a higher proportion of
G. haemolysans
than saliva samples from patients with periodontitis. Growth inhibition assays indicated that the protein components contained in the culture supernatant of
G. haemolysans
directly suppressed the growth of
P. gingivalis
. This study shows that the presence of
G. haemolysans
in saliva is associated with periodontal health and that it inhibits the growth of
P. gingivalis
in vitro.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-021-91267-3</identifier><identifier>PMID: 34083694</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/326/107 ; 631/326/2565/547 ; Adult ; Aged ; Antibiosis ; Bacteria ; Bacterial Typing Techniques ; Case-Control Studies ; Female ; Gemella - physiology ; Gemella haemolysans ; Hemolysis ; Humanities and Social Sciences ; Humans ; Male ; Microbiomes ; Middle Aged ; Mouth - microbiology ; multidisciplinary ; Oral cavity ; Pathogens ; Periodontal diseases ; Periodontal Diseases - microbiology ; Periodontitis ; Porphyromonas gingivalis ; Porphyromonas gingivalis - physiology ; Saliva ; Saliva - microbiology ; Science ; Science (multidisciplinary)</subject><ispartof>Scientific reports, 2021-06, Vol.11 (1), p.11742-12, Article 11742</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c606t-de4768d0a255a894ce7776376975fca8f9679e0d2b3b9d61d3d9b8ea09507adc3</citedby><cites>FETCH-LOGICAL-c606t-de4768d0a255a894ce7776376975fca8f9679e0d2b3b9d61d3d9b8ea09507adc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2536653390/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2536653390?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25732,27903,27904,36991,36992,44569,53770,53772,74873</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34083694$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyoshi, Tomohiro</creatorcontrib><creatorcontrib>Oge, Shogo</creatorcontrib><creatorcontrib>Nakata, Satoshi</creatorcontrib><creatorcontrib>Ueno, Yuji</creatorcontrib><creatorcontrib>Ukita, Hidehiko</creatorcontrib><creatorcontrib>Kousaka, Reiko</creatorcontrib><creatorcontrib>Miura, Yuki</creatorcontrib><creatorcontrib>Yoshinari, Nobuo</creatorcontrib><creatorcontrib>Yoshida, Akihiro</creatorcontrib><title>Gemella haemolysans inhibits the growth of the periodontal pathogen Porphyromonas gingivalis</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The oral microbiome plays an important role in the human microbial community and in maintaining the health of an individual. Imbalances in the oral microbiome may contribute to oral and systemic diseases. The progression of periodontal disease is closely related to the growth of bacteria, such as
Porphyromonas gingivalis
, in the oral cavity. However, the pathogen growth mechanism specific to periodontal disease remains unknown. This study aimed to identify bacteria associated with periodontal health by focusing on hemolytic bacteria. Unstimulated saliva samples were collected from ten periodontitis patients and five healthy subjects to detect and identify the presence of hemolytic bacteria. The saliva of healthy subjects contained a higher proportion of
G. haemolysans
than saliva samples from patients with periodontitis. Growth inhibition assays indicated that the protein components contained in the culture supernatant of
G. haemolysans
directly suppressed the growth of
P. gingivalis
. This study shows that the presence of
G. haemolysans
in saliva is associated with periodontal health and that it inhibits the growth of
P. gingivalis
in vitro.</description><subject>631/326/107</subject><subject>631/326/2565/547</subject><subject>Adult</subject><subject>Aged</subject><subject>Antibiosis</subject><subject>Bacteria</subject><subject>Bacterial Typing Techniques</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Gemella - physiology</subject><subject>Gemella haemolysans</subject><subject>Hemolysis</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Male</subject><subject>Microbiomes</subject><subject>Middle Aged</subject><subject>Mouth - microbiology</subject><subject>multidisciplinary</subject><subject>Oral cavity</subject><subject>Pathogens</subject><subject>Periodontal diseases</subject><subject>Periodontal Diseases - microbiology</subject><subject>Periodontitis</subject><subject>Porphyromonas gingivalis</subject><subject>Porphyromonas gingivalis - physiology</subject><subject>Saliva</subject><subject>Saliva - microbiology</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9kstu1DAUQCMEolXpD7BAkdiwSfH7sUFCFbSVKtFFu0OyHNtJPErsYGeK5u_xTEppWdQbP-65x69bVe8hOIMAi8-ZQCpFAxBsJESMN_hVdYwAoQ3CCL1-Mj6qTnPegNIokgTKt9URJkBgJslx9fPCTW4cdT1oN8Vxl3XItQ-Db_2S62VwdZ_i72WoY3eYzS75aGNY9FjPehli70J9E9M87FKcYtC57n3o_b0efX5Xven0mN3pQ39S3X3_dnt-2Vz_uLg6_3rdGAbY0lhHOBMWaESpFpIYxzlnmDPJaWe06CTj0gGLWtxKy6DFVrbCaSAp4NoafFJdrV4b9UbNyU867VTUXh0WYuqVTos3o1PICGMowrA4ibVQuo4yBCQTrKMQkOL6srrmbTs5a1xYkh6fSZ9Hgh9UH--VgJxyRIvg04MgxV9blxc1-Wz2bxxc3GZVEM4IogwW9ON_6CZuUyhPtacYoxhLUCi0UibFnJPrHg8DgdrXglprQZVaUIdaULgkfXh6jceUvz9fALwCuYRC79K_vV_Q_gGODMAQ</recordid><startdate>20210603</startdate><enddate>20210603</enddate><creator>Miyoshi, Tomohiro</creator><creator>Oge, Shogo</creator><creator>Nakata, Satoshi</creator><creator>Ueno, Yuji</creator><creator>Ukita, Hidehiko</creator><creator>Kousaka, Reiko</creator><creator>Miura, Yuki</creator><creator>Yoshinari, Nobuo</creator><creator>Yoshida, Akihiro</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><general>Nature Portfolio</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20210603</creationdate><title>Gemella haemolysans inhibits the growth of the periodontal pathogen Porphyromonas gingivalis</title><author>Miyoshi, Tomohiro ; Oge, Shogo ; Nakata, Satoshi ; Ueno, Yuji ; Ukita, Hidehiko ; Kousaka, Reiko ; Miura, Yuki ; Yoshinari, Nobuo ; Yoshida, Akihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c606t-de4768d0a255a894ce7776376975fca8f9679e0d2b3b9d61d3d9b8ea09507adc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>631/326/107</topic><topic>631/326/2565/547</topic><topic>Adult</topic><topic>Aged</topic><topic>Antibiosis</topic><topic>Bacteria</topic><topic>Bacterial Typing Techniques</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Gemella - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyoshi, Tomohiro</au><au>Oge, Shogo</au><au>Nakata, Satoshi</au><au>Ueno, Yuji</au><au>Ukita, Hidehiko</au><au>Kousaka, Reiko</au><au>Miura, Yuki</au><au>Yoshinari, Nobuo</au><au>Yoshida, Akihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gemella haemolysans inhibits the growth of the periodontal pathogen Porphyromonas gingivalis</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2021-06-03</date><risdate>2021</risdate><volume>11</volume><issue>1</issue><spage>11742</spage><epage>12</epage><pages>11742-12</pages><artnum>11742</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The oral microbiome plays an important role in the human microbial community and in maintaining the health of an individual. Imbalances in the oral microbiome may contribute to oral and systemic diseases. The progression of periodontal disease is closely related to the growth of bacteria, such as
Porphyromonas gingivalis
, in the oral cavity. However, the pathogen growth mechanism specific to periodontal disease remains unknown. This study aimed to identify bacteria associated with periodontal health by focusing on hemolytic bacteria. Unstimulated saliva samples were collected from ten periodontitis patients and five healthy subjects to detect and identify the presence of hemolytic bacteria. The saliva of healthy subjects contained a higher proportion of
G. haemolysans
than saliva samples from patients with periodontitis. Growth inhibition assays indicated that the protein components contained in the culture supernatant of
G. haemolysans
directly suppressed the growth of
P. gingivalis
. This study shows that the presence of
G. haemolysans
in saliva is associated with periodontal health and that it inhibits the growth of
P. gingivalis
in vitro.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>34083694</pmid><doi>10.1038/s41598-021-91267-3</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| source | Publicly Available Content (ProQuest); PubMed Central; Free Full-Text Journals in Chemistry; Springer Nature - nature.com Journals - Fully Open Access |
| subjects | 631/326/107 631/326/2565/547 Adult Aged Antibiosis Bacteria Bacterial Typing Techniques Case-Control Studies Female Gemella - physiology Gemella haemolysans Hemolysis Humanities and Social Sciences Humans Male Microbiomes Middle Aged Mouth - microbiology multidisciplinary Oral cavity Pathogens Periodontal diseases Periodontal Diseases - microbiology Periodontitis Porphyromonas gingivalis Porphyromonas gingivalis - physiology Saliva Saliva - microbiology Science Science (multidisciplinary) |
| title | Gemella haemolysans inhibits the growth of the periodontal pathogen Porphyromonas gingivalis |
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