Repeated caffeine intake suppresses cerebral grey matter responses to chronic sleep restriction in an A1 adenosine receptor-dependent manner: a double-blind randomized controlled study with PET-MRI

• Published in: Scientific reports 2024-06, Vol.14 (1), p.12724-12
• Main Authors: Lin, Yu-Shiuan, Lange, Denise, Baur, Diego Manuel, Foerges, Anna, Chu, Congying, Li, Changhong, Elmenhorst, Eva-Maria, Neumaier, Bernd, Bauer, Andreas, Aeschbach, Daniel, Landolt, Hans-Peter, Elmenhorst, David
• Format: Article
• Language: English
• Subjects: 631/378/1385/1815; 631/45/882; 631/92/436/2387; Adenosine; Adenosine A2A receptors; Blood flow; Brain; Caffeine; Cerebral blood flow; Coffee; Humanities and Social Sciences; Magnetic resonance imaging; Morphometry; multidisciplinary; Neuroimaging; Plasticity; Positron emission tomography; Prefrontal cortex; Science; Science (multidisciplinary); Sleep; Sleep and wakefulness; Sleep deprivation; Substantia grisea; Temporal lobe; Thalamus
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-61421-8

Evidence has shown that both sleep loss and daily caffeine intake can induce changes in grey matter (GM). Caffeine is frequently used to combat sleepiness and impaired performance caused by insufficient sleep. It is unclear (1) whether daily use of caffeine could prevent or exacerbate the GM alterations induced by 5-day sleep restriction (i.e. chronic sleep restriction, CSR), and (2) whether the potential impact on GM plasticity depends on individual differences in the availability of adenosine receptors, which are involved in mediating effects of caffeine on sleep and waking function. Thirty-six healthy adults participated in this double-blind, randomized, controlled study (age = 28.9 ± 5.2 y/; F:M = 15:21; habitual level of caffeine intake