Surface modification of silicone elastomer with rosin acid-based quaternary ammonium salt for antimicrobial and biocompatible properties

Despite advanced sterilized and aseptic techniques, biomaterial-associated infections are still posing a great threat to human life. Therefore, constructing antimicrobial coating that exerts potent antimicrobial activity combined with low cytotoxicity is of great significance. Herein, an antimicrobi...

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Bibliographic Details
Published in:Materials & design 2020-04, Vol.189, p.108493, Article 108493
Main Authors: Li, Zhaoshuang, Liu, He, Xu, Xu, Ma, Lina, Shang, Shibin, Song, Zhanqian
Format: Article
Language:English
Subjects:
Antimicrobial coating
Biocompatibility
Healthcare
Quaternary ammonium salt
Rosin acid
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Summary:Despite advanced sterilized and aseptic techniques, biomaterial-associated infections are still posing a great threat to human life. Therefore, constructing antimicrobial coating that exerts potent antimicrobial activity combined with low cytotoxicity is of great significance. Herein, an antimicrobial coating on the surface of silicone elastomer (PDMS) has been successful constructed, which based on maleopimaric acid quaternary ammonium cation (MPA-N+). The surface morphology and chemical composition of modified PDMS (PDMS-g-MPA-N+) were confirmed by scanning electron microscopy (SEM), energy dispersive spectrometry (EDS), and X-ray photoelectron spectroscopy (XPS). The PDMS-g-MPA-N+ possess excellent antimicrobial activity against both Gram-positive bacterial (Staphylococcus aureus) and Gram-negative bacterial (Escherichia coli, Pseudomonas aeruginosa) strains. In addition, confocal laser scanning microscopy imaging demonstrated that it also can effectively inhibit bacterial biofilm formation over 5 days. Most importantly, PDMS-g-MPA-N+ exhibited excellent biocompatibility, which induced no significant hemolysis and cytotoxicity toward mammalian cells. The study demonstrated that the silicone elastomer surface grafted with MPA-N+ enabled the incorporation of a renewable biomass to effectively combat bacteria and biofilm formation for biomedical applications. [Display omitted] •A quaternary ammonium salt from rosin acid was used to enhance the antimicrobial properties of silicone elastomer.•The antimicrobial silicone elastomer exhibits excellent hemocompatibility and biocompatibility.•This work provides an idea for application of renewable resources in the field of biomedical materials.
ISSN:0264-1275
1873-4197
DOI:10.1016/j.matdes.2020.108493