Potential of Secondary Metabolites of Diaporthe Species Associated with Terrestrial and Marine Origins

species produce versatile secondary metabolites (SMs), including terpenoids, fatty acids, polyketides, steroids, and alkaloids. These structurally diverse SMs exhibit a wide range of biological activities, including cytotoxic, antifungal, antibacterial, antiviral, antioxidant, anti-inflammatory, and...

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Bibliographic Details
Published in:Journal of fungi (Basel) 2023-04, Vol.9 (4), p.453
Main Authors: Wei, Wei, Khan, Babar, Dai, Qun, Lin, Jie, Kang, Liqin, Rajput, Nasir Ahmed, Yan, Wei, Liu, Guiyou
Format: Article
Language:English
Subjects:
Bioactive compounds
biological potencies
Cancer
Cytotoxicity
Diaporthe
drug discovery
E coli
Fatty acids
Fungi
Herbal medicine
Inflammation
Leukemia
Metabolites
Natural products
Pathogens
Polyketides
Review
Secondary metabolites
Steroid hormones
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Summary:species produce versatile secondary metabolites (SMs), including terpenoids, fatty acids, polyketides, steroids, and alkaloids. These structurally diverse SMs exhibit a wide range of biological activities, including cytotoxic, antifungal, antibacterial, antiviral, antioxidant, anti-inflammatory, and phytotoxic activities, which could be exploited in the medical, agricultural, and other modern industries. This review comprehensively covers the production and biological potencies of isolated natural products from the genus associated with terrestrial and marine origins. A total of 275 SMs have been summarized from terrestrial (153; 55%) and marine (110; 41%) origins during the last twelve years, and 12 (4%) compounds are common to both environments. All secondary metabolites are categorized predominantly on the basis of their bioactivities (cytotoxic, antibacterial, antifungal, and miscellaneous activity). Overall, 134 bioactive compounds were isolated from terrestrial (92; 55%) and marine (42; 34%) origins, but about half the compounds did not report any kind of activity. The antiSMASH results suggested that strains are capable of encoding a wide range of SMs and have tremendous biosynthetic potential for new SMs. This study will be useful for future research on drug discovery from terrestrial and marine natural products.
ISSN:2309-608X
2309-608X
DOI:10.3390/jof9040453