Open necrosectomy combined with continuous positive drainage and prophylactic diverting loop ileostomy for late infected pancreatic necrosis: a retrospective cohort study

• Published in: BMC gastroenterology 2020-07, Vol.20 (1), p.212-212, Article 212
• Main Authors: Niu, Dong-Guang, Li, Wei-Qin, Huang, Qian, Yang, Fan, Tian, Wei-Liang, Li, Chen, Ding, Lian-An, Fang, Hong-Chun, Zhao, Yun-Zhao
• Format: Article
• Language: English
• Subjects: Abdomen; Care and treatment; Cohort analysis; Colon; Continuous positive drainage; Digestive system surgery; Disease; Drainage; Drainage (Surgical); Endoscopy; Fistula; Gastroenterology; Hemorrhage; Hospitals; Humans; Ileostomy; Ileostomy - adverse effects; Infected pancreatic necrosis; Intestine; Intraabdominal Infections; Ischemia; Laparotomy; Methods; Mortality; Necrosis; Open necrosectomy; Ostomy; Pancreas; Pancreatic diseases; Pancreatitis, Acute Necrotizing - surgery; Patients; Performance evaluation; Postoperative Complications - etiology; Postoperative Complications - prevention & control; Prophylactic diverting loop ileostomy; Retrospective Studies; Sepsis; Statistical analysis; Suctioning; Surgery; Surgical drains; Trauma; Treatment Outcome; Wound drainage
• ISSN: 1471-230X; 1471-230X
• DOI: 10.1186/s12876-020-01343-7

To evaluate an innovative open necrosectomy strategy with continuous positive drainage and prophylactic diverting loop ileostomy for the management of late infected pancreatic necrosis (LIPN). Consecutive patients were divided into open necrosectomy (ON) group (n = 23), open necrosectomy with colonic segment resection (ON+CSR) group (n = 8) and open necrosectomy with prophylactic diverting loop ileostomy (ON+PDLI) group (n = 11). Continuous positive drainage (CPD) via double-lumen irrigation-suction tube (DLIST) was performed in ON+PDLI group. The primary endpoints were duration of organ failure after surgery, postoperative complication, the rate of re-surgery and mortality. The secondary endpoints were duration of hospitalization, cost, time interval between open surgery and total enteral nutrition (TEN). The recovery time of organ function in ON+PDLI group was shorter than that in other two groups. Colonic complications occurred in 13 patients (56.5%) in the ON group and 3 patients (27.3%) in the ON+PDLI group (p = 0.11). The length of stay in the ON+PDLI group was shorter than the ON group (p = 0.001). The hospitalization cost in the ON+PDLI group was less than the ON group (p = 0.0052). ON+PDLI can avoid the intestinal dysfunction, re-ileostomy, the resection of innocent colon and reduce the intraoperative trauma. Despite being of colonic complications before or during operation, CPD + PDLI may show superior effectiveness, safety, and convenience in LIPN.