Cytochrome P450 Enzyme Design by Constraining the Catalytic Pocket in a Diffusion Model

Although cytochrome P450 enzymes are the most versatile biocatalysts in nature, there is insufficient comprehension of the molecular mechanism underlying their functional innovation process. Here, by combining ancestral sequence reconstruction, reverse mutation assay, and progressive forward accumul...

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Bibliographic Details
Published in:Research 2024-01, Vol.7, p.0413
Main Authors: Wang, Qian, Liu, Xiaonan, Zhang, Hejian, Chu, Huanyu, Shi, Chao, Zhang, Lei, Bai, Jie, Liu, Pi, Li, Jing, Zhu, Xiaoxi, Liu, Yuwan, Chen, Zhangxin, Huang, Rong, Chang, Hong, Liu, Tian, Chang, Zhenzhan, Cheng, Jian, Jiang, Huifeng
Format: Article
Language:English
Subjects:
Biocatalysts
Cytochrome P450
Cytochromes P450
Enzymes
Innovations
Molecular modelling
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