Higher mortality of severe influenza patients with probable aspergillosis than those with and without other coinfections

Background/Purpose Aspergillus -associated infection might comprise up to 23–29% of severe influenza patients from the community throughout stay in an intensive care unit (ICU). In Taiwan, cases of severe influenza with aspergillosis are increasingly reported. Therefore, we describe the relative ris...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the Formosan Medical Association 2017-09, Vol.116 (9), p.660-670
Main Authors: Ku, Yee-Huang, Chan, Khee-Siang, Yang, Chun-Chieh, Tan, Che-Kim, Chuang, Yin-Ching, Yu, Wen-Liang
Format: Article
Language:English
Subjects:
Aged
Aspergillosis
Aspergillosis - diagnostic imaging
Aspergillosis - mortality
Coinfection
Coinfection - diagnostic imaging
Coinfection - mortality
Female
Galactomannan
Hospital Mortality
Humans
Influenza
Influenza, Human - diagnostic imaging
Influenza, Human - mortality
Intensive Care Units
Internal Medicine
Male
Middle Aged
Mortality
Retrospective Studies
Risk Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background/Purpose Aspergillus -associated infection might comprise up to 23–29% of severe influenza patients from the community throughout stay in an intensive care unit (ICU). In Taiwan, cases of severe influenza with aspergillosis are increasingly reported. Therefore, we describe the relative risk of mortality among severe influenza patients with aspergillosis and other coinfections compared to severe influenza patients without Aspergillus coinfections. Methods We retrospectively reviewed 124 adult patients with severe influenza in a tertiary medical center in southern Taiwan from January 2015 through March 2016. The definition of probable aspergillosis required abnormal radiological findings and positive Aspergillus galactomannan (GM) antigen and/or Aspergillus isolation. Results Probable aspergillosis (detected throughout the whole course) and other coinfections (only community-acquired) were diagnosed in 21 (17%) and 38 (31%) of all patients respectively. Klebsiella pneumoniae (36.8%), Pseudomonas aeruginosa (31.6%) and Staphylococcus aureus (31.6%) were the most frequent isolates of other coinfections. In-ICU mortality of Aspergillus group (66.7%) was significantly higher than other coinfections (23.7%, p  = 0.001) or control group without coinfections (15.4%, p  
ISSN:0929-6646
1876-0821
DOI:10.1016/j.jfma.2017.06.002