Soluble Receptor of Advanced Glycation End-Products (sRAGE) in Pediatric Asthma: A Prospective Study in 68 Children Aged 7 Years

Background: Asthma is a chronic inflammatory disease of the airways common in children. Soluble advanced glycation end-product receptor (sRAGE) is a blood biomarker of lung damage and inflammation. We sought to determine whether it could also be a biomarker in childhood asthma. Methods: We conducted...

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Bibliographic Details
Published in:Applied sciences 2022-06, Vol.12 (12), p.5926
Main Authors: Magnier, Julie, Julian, Valérie, Sapin, Vincent, Mulliez, Aurélien, Usclade, Alexandra, Rochette, Emmanuelle, Evrard, Bertrand, Labbe, André, Coste, Karen, Egron, Carole
Format: Article
Language:English
Subjects:
Advanced glycosylation end products
Age
Asthma
biomarker
Biomarkers
Chemical Sciences
Children
Children & youth
Dermatitis
Families & family life
Glycosylation
Inflammation
Inflammatory diseases
Ligands
Mortality
Pathogenesis
Pediatrics
Plasma
Questionnaires
Respiratory function
Spirometry
sRAGE
Statistical analysis
Tobacco
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Summary:Background: Asthma is a chronic inflammatory disease of the airways common in children. Soluble advanced glycation end-product receptor (sRAGE) is a blood biomarker of lung damage and inflammation. We sought to determine whether it could also be a biomarker in childhood asthma. Methods: We conducted a prospective, observational, analytical study at Clermont-Ferrand University Hospital. We measured plasma sRAGE levels in asthmatic and healthy children aged 7 years. Results: Of the 68 children assessed, 15 (22.05%) presented asthma. All presented normal respiratory function. The mean plasma sRAGE level was 1875 pg/mL in the children with asthma and 1794 pg/mL in the healthy children (p = 0.525). The mean plasma sRAGE level was significantly decreased with tobacco exposure during pregnancy: 1478 pg/mL versus 1870 pg/mL without (p = 0.007). Lower levels were observed in children living in apartments (1557 pg/mL) than in those living in houses (1863 pg/mL) (p = 0.031). Conclusions: No difference was observed in plasma sRAGE levels in children with asthma in our well-treated and controlled population. Environmental exposure may affect these levels. Further studies are required to better characterize the role of sRAGE.
ISSN:2076-3417
2076-3417
DOI:10.3390/app12125926