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Association of thyroid hormones with the severity of chronic kidney disease: a cross-sectional observational study at Tabuk, Saudi Arabia
The interplay between chronic kidney disease (CKD) and thyroid dysfunction is becoming more evident in the biomedical community. However, the intricacies of their relationship warrant deeper investigation to understand the clinical implications fully. This study aims to systematically evaluate the c...
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| creator | Awwaadh, Basmah Mohammed, Amal Hussain Alharbi, Basmah F Alruwetei, Abdulmohsen Sarwar, Tarique Alharbi, Hajed Obaid Alhumaydhi, Fahad |
| description | The interplay between chronic kidney disease (CKD) and thyroid dysfunction is becoming more evident in the biomedical community. However, the intricacies of their relationship warrant deeper investigation to understand the clinical implications fully.
This study aims to systematically evaluate the correlation between thyroid hormone levels, including thyroid-stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4), and markers of renal disease severity. These markers include serum creatinine, urea, and parathyroid hormone (PTH) levels in individuals diagnosed with CK).
We conducted a cross-sectional observational study involving a cohort of 86 participants with CKD recruited from the renal clinic at King Fahad Hospital in Tabuk. Biochemical parameters, encompassing plasma electrolytes and thyroid hormone concentrations, were quantitatively assessed. These measurements were performed with the aid of a Roche Cobas E411 analyzer. The Pearson correlation coefficient was employed to delineate the strength and direction of the associations between the thyroid function markers and renal disease indicators.
The statistical analysis highlighted a generally weak correlation between the concentrations of thyroid hormones and the indicators of renal disease severity, with Pearson correlation coefficients between -0.319 and 0.815. Critically, no significant correlation was found between creatinine and thyroid hormones (TSH, T3, T4), nor was any substantial correlation between urea and thyroid hormones. Conversely, a robust positive correlation was noted between the levels of parathyroid hormone and serum creatinine (
= 0.718,
|
| doi_str_mv | 10.7717/peerj.18338 |
| format | article |
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This study aims to systematically evaluate the correlation between thyroid hormone levels, including thyroid-stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4), and markers of renal disease severity. These markers include serum creatinine, urea, and parathyroid hormone (PTH) levels in individuals diagnosed with CK).
We conducted a cross-sectional observational study involving a cohort of 86 participants with CKD recruited from the renal clinic at King Fahad Hospital in Tabuk. Biochemical parameters, encompassing plasma electrolytes and thyroid hormone concentrations, were quantitatively assessed. These measurements were performed with the aid of a Roche Cobas E411 analyzer. The Pearson correlation coefficient was employed to delineate the strength and direction of the associations between the thyroid function markers and renal disease indicators.
The statistical analysis highlighted a generally weak correlation between the concentrations of thyroid hormones and the indicators of renal disease severity, with Pearson correlation coefficients between -0.319 and 0.815. Critically, no significant correlation was found between creatinine and thyroid hormones (TSH, T3, T4), nor was any substantial correlation between urea and thyroid hormones. Conversely, a robust positive correlation was noted between the levels of parathyroid hormone and serum creatinine (
= 0.718,
< 0.001).
The data suggests that thyroid hormone levels have a minimal correlation with the severity of renal disease markers. In contrast, the pronounced correlation between PTH and creatinine underscores the importance of considering PTH as a significant factor in managing and therapeutic intervention of CKD complications. These initial findings catalyze further research to thoroughly investigate the pathophysiological relationships and potential therapeutic targets concerning thyroid dysfunction in patients with renal impairment.</description><identifier>ISSN: 2167-8359</identifier><identifier>EISSN: 2167-8359</identifier><identifier>DOI: 10.7717/peerj.18338</identifier><identifier>PMID: 39484207</identifier><language>eng</language><publisher>United States: PeerJ. Ltd</publisher><subject>Adult ; Aged ; Analysis ; Biochemistry ; Biomarkers - blood ; Chronic kidney failure ; Creatinine - blood ; Cross-Sectional Studies ; Development and progression ; Diabetes and Endocrinology ; Epidemiology ; Ethylenediaminetetraacetic acid ; Female ; Health aspects ; Hematology ; Humans ; Male ; Middle Aged ; Nephrology ; Parathyroid hormone ; Parathyroid Hormone - blood ; Renal Insufficiency, Chronic - blood ; Renal Insufficiency, Chronic - epidemiology ; Renal Insufficiency, Chronic - physiopathology ; Saudi Arabia ; Saudi Arabia - epidemiology ; Severity of Illness Index ; Thyroid diseases ; Thyroid gland ; Thyroid hormones ; Thyroid Hormones - blood ; Thyrotropin ; Thyrotropin - blood ; Thyroxine ; Thyroxine - blood ; Triiodothyronine - blood ; Urea ; Urea - blood</subject><ispartof>PeerJ (San Francisco, CA), 2024-10, Vol.12, p.e18338, Article e18338</ispartof><rights>2024 Awwaadh et al.</rights><rights>COPYRIGHT 2024 PeerJ. Ltd.</rights><rights>2024 Awwaadh et al. 2024 Awwaadh et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c434t-7d9cda51747e34256337ed09635c8ad07bf21ec0d38927d13a577422c8d820de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526795/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526795/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,36992,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39484207$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Awwaadh, Basmah</creatorcontrib><creatorcontrib>Mohammed, Amal Hussain</creatorcontrib><creatorcontrib>Alharbi, Basmah F</creatorcontrib><creatorcontrib>Alruwetei, Abdulmohsen</creatorcontrib><creatorcontrib>Sarwar, Tarique</creatorcontrib><creatorcontrib>Alharbi, Hajed Obaid</creatorcontrib><creatorcontrib>Alhumaydhi, Fahad</creatorcontrib><title>Association of thyroid hormones with the severity of chronic kidney disease: a cross-sectional observational study at Tabuk, Saudi Arabia</title><title>PeerJ (San Francisco, CA)</title><addtitle>PeerJ</addtitle><description>The interplay between chronic kidney disease (CKD) and thyroid dysfunction is becoming more evident in the biomedical community. However, the intricacies of their relationship warrant deeper investigation to understand the clinical implications fully.
This study aims to systematically evaluate the correlation between thyroid hormone levels, including thyroid-stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4), and markers of renal disease severity. These markers include serum creatinine, urea, and parathyroid hormone (PTH) levels in individuals diagnosed with CK).
We conducted a cross-sectional observational study involving a cohort of 86 participants with CKD recruited from the renal clinic at King Fahad Hospital in Tabuk. Biochemical parameters, encompassing plasma electrolytes and thyroid hormone concentrations, were quantitatively assessed. These measurements were performed with the aid of a Roche Cobas E411 analyzer. The Pearson correlation coefficient was employed to delineate the strength and direction of the associations between the thyroid function markers and renal disease indicators.
The statistical analysis highlighted a generally weak correlation between the concentrations of thyroid hormones and the indicators of renal disease severity, with Pearson correlation coefficients between -0.319 and 0.815. Critically, no significant correlation was found between creatinine and thyroid hormones (TSH, T3, T4), nor was any substantial correlation between urea and thyroid hormones. Conversely, a robust positive correlation was noted between the levels of parathyroid hormone and serum creatinine (
= 0.718,
< 0.001).
The data suggests that thyroid hormone levels have a minimal correlation with the severity of renal disease markers. In contrast, the pronounced correlation between PTH and creatinine underscores the importance of considering PTH as a significant factor in managing and therapeutic intervention of CKD complications. These initial findings catalyze further research to thoroughly investigate the pathophysiological relationships and potential therapeutic targets concerning thyroid dysfunction in patients with renal impairment.</description><subject>Adult</subject><subject>Aged</subject><subject>Analysis</subject><subject>Biochemistry</subject><subject>Biomarkers - blood</subject><subject>Chronic kidney failure</subject><subject>Creatinine - blood</subject><subject>Cross-Sectional Studies</subject><subject>Development and progression</subject><subject>Diabetes and Endocrinology</subject><subject>Epidemiology</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Female</subject><subject>Health aspects</subject><subject>Hematology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nephrology</subject><subject>Parathyroid hormone</subject><subject>Parathyroid Hormone - blood</subject><subject>Renal Insufficiency, Chronic - blood</subject><subject>Renal Insufficiency, Chronic - epidemiology</subject><subject>Renal Insufficiency, Chronic - physiopathology</subject><subject>Saudi Arabia</subject><subject>Saudi Arabia - epidemiology</subject><subject>Severity of Illness Index</subject><subject>Thyroid diseases</subject><subject>Thyroid gland</subject><subject>Thyroid hormones</subject><subject>Thyroid Hormones - blood</subject><subject>Thyrotropin</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine</subject><subject>Thyroxine - blood</subject><subject>Triiodothyronine - blood</subject><subject>Urea</subject><subject>Urea - blood</subject><issn>2167-8359</issn><issn>2167-8359</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNptkluLEzEUgAdR3GXdJ98lIIigrbnMTDK-SFm8LCz44PocziRnOulOJzWZqfQn-K_NtHVpweQhycmXjyTnZNlLRudSMvlhgxhWc6aEUE-yS85KOVOiqJ6ezC-y6xhXNDXFS6rE8-xCVLnKOZWX2Z9FjN44GJzviW_I0O6Cd5a0Pqx9j5H8dkObokgibjG4YTdRpg2-d4Y8ONvjjlgXESJ-JEBM8DHOIppJCB3xdcSwheMqDqPdERjIPdTjw3vyA0bryCJA7eBF9qyBLuL1cbzKfn75fH_zbXb3_evtzeJuZnKRDzNpK2OhYDKXKHJelEJItLQqRWEUWCrrhjM01ApVcWmZgELKnHOjrOLUorjKbg9e62GlN8GtIey0B6f3AR-WGsLgTIdaFMwKUapkafJC1jVlQinBFErguZhcnw6uzViv0RrshwDdmfR8p3etXvqtZqzgpayKZHh7NAT_a8Q46LWLBrsOevRj1IJxQWVJaZnQ1wd0Celurm98UpoJ1wvFclrR9NJEzf9DpW5x7UxKaeNS_OzAm5MDLUI3tNF345SyeA6-O4D7HAdsHt_JqJ6KUe-LUe-LMdGvTr_mkf1XeuIv5snaWw</recordid><startdate>20241028</startdate><enddate>20241028</enddate><creator>Awwaadh, Basmah</creator><creator>Mohammed, Amal Hussain</creator><creator>Alharbi, Basmah F</creator><creator>Alruwetei, Abdulmohsen</creator><creator>Sarwar, Tarique</creator><creator>Alharbi, Hajed Obaid</creator><creator>Alhumaydhi, Fahad</creator><general>PeerJ. Ltd</general><general>PeerJ Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20241028</creationdate><title>Association of thyroid hormones with the severity of chronic kidney disease: a cross-sectional observational study at Tabuk, Saudi Arabia</title><author>Awwaadh, Basmah ; Mohammed, Amal Hussain ; Alharbi, Basmah F ; Alruwetei, Abdulmohsen ; Sarwar, Tarique ; Alharbi, Hajed Obaid ; Alhumaydhi, Fahad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-7d9cda51747e34256337ed09635c8ad07bf21ec0d38927d13a577422c8d820de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Analysis</topic><topic>Biochemistry</topic><topic>Biomarkers - blood</topic><topic>Chronic kidney failure</topic><topic>Creatinine - blood</topic><topic>Cross-Sectional Studies</topic><topic>Development and progression</topic><topic>Diabetes and Endocrinology</topic><topic>Epidemiology</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Female</topic><topic>Health aspects</topic><topic>Hematology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nephrology</topic><topic>Parathyroid hormone</topic><topic>Parathyroid Hormone - blood</topic><topic>Renal Insufficiency, Chronic - blood</topic><topic>Renal Insufficiency, Chronic - epidemiology</topic><topic>Renal Insufficiency, Chronic - physiopathology</topic><topic>Saudi Arabia</topic><topic>Saudi Arabia - epidemiology</topic><topic>Severity of Illness Index</topic><topic>Thyroid diseases</topic><topic>Thyroid gland</topic><topic>Thyroid hormones</topic><topic>Thyroid Hormones - blood</topic><topic>Thyrotropin</topic><topic>Thyrotropin - blood</topic><topic>Thyroxine</topic><topic>Thyroxine - blood</topic><topic>Triiodothyronine - blood</topic><topic>Urea</topic><topic>Urea - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Awwaadh, Basmah</creatorcontrib><creatorcontrib>Mohammed, Amal Hussain</creatorcontrib><creatorcontrib>Alharbi, Basmah F</creatorcontrib><creatorcontrib>Alruwetei, Abdulmohsen</creatorcontrib><creatorcontrib>Sarwar, Tarique</creatorcontrib><creatorcontrib>Alharbi, Hajed Obaid</creatorcontrib><creatorcontrib>Alhumaydhi, Fahad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PeerJ (San Francisco, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Awwaadh, Basmah</au><au>Mohammed, Amal Hussain</au><au>Alharbi, Basmah F</au><au>Alruwetei, Abdulmohsen</au><au>Sarwar, Tarique</au><au>Alharbi, Hajed Obaid</au><au>Alhumaydhi, Fahad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of thyroid hormones with the severity of chronic kidney disease: a cross-sectional observational study at Tabuk, Saudi Arabia</atitle><jtitle>PeerJ (San Francisco, CA)</jtitle><addtitle>PeerJ</addtitle><date>2024-10-28</date><risdate>2024</risdate><volume>12</volume><spage>e18338</spage><pages>e18338-</pages><artnum>e18338</artnum><issn>2167-8359</issn><eissn>2167-8359</eissn><abstract>The interplay between chronic kidney disease (CKD) and thyroid dysfunction is becoming more evident in the biomedical community. However, the intricacies of their relationship warrant deeper investigation to understand the clinical implications fully.
This study aims to systematically evaluate the correlation between thyroid hormone levels, including thyroid-stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4), and markers of renal disease severity. These markers include serum creatinine, urea, and parathyroid hormone (PTH) levels in individuals diagnosed with CK).
We conducted a cross-sectional observational study involving a cohort of 86 participants with CKD recruited from the renal clinic at King Fahad Hospital in Tabuk. Biochemical parameters, encompassing plasma electrolytes and thyroid hormone concentrations, were quantitatively assessed. These measurements were performed with the aid of a Roche Cobas E411 analyzer. The Pearson correlation coefficient was employed to delineate the strength and direction of the associations between the thyroid function markers and renal disease indicators.
The statistical analysis highlighted a generally weak correlation between the concentrations of thyroid hormones and the indicators of renal disease severity, with Pearson correlation coefficients between -0.319 and 0.815. Critically, no significant correlation was found between creatinine and thyroid hormones (TSH, T3, T4), nor was any substantial correlation between urea and thyroid hormones. Conversely, a robust positive correlation was noted between the levels of parathyroid hormone and serum creatinine (
= 0.718,
< 0.001).
The data suggests that thyroid hormone levels have a minimal correlation with the severity of renal disease markers. In contrast, the pronounced correlation between PTH and creatinine underscores the importance of considering PTH as a significant factor in managing and therapeutic intervention of CKD complications. These initial findings catalyze further research to thoroughly investigate the pathophysiological relationships and potential therapeutic targets concerning thyroid dysfunction in patients with renal impairment.</abstract><cop>United States</cop><pub>PeerJ. Ltd</pub><pmid>39484207</pmid><doi>10.7717/peerj.18338</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Analysis Biochemistry Biomarkers - blood Chronic kidney failure Creatinine - blood Cross-Sectional Studies Development and progression Diabetes and Endocrinology Epidemiology Ethylenediaminetetraacetic acid Female Health aspects Hematology Humans Male Middle Aged Nephrology Parathyroid hormone Parathyroid Hormone - blood Renal Insufficiency, Chronic - blood Renal Insufficiency, Chronic - epidemiology Renal Insufficiency, Chronic - physiopathology Saudi Arabia Saudi Arabia - epidemiology Severity of Illness Index Thyroid diseases Thyroid gland Thyroid hormones Thyroid Hormones - blood Thyrotropin Thyrotropin - blood Thyroxine Thyroxine - blood Triiodothyronine - blood Urea Urea - blood |
| title | Association of thyroid hormones with the severity of chronic kidney disease: a cross-sectional observational study at Tabuk, Saudi Arabia |
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