The role of sentinel node tumor burden in modeling the prognosis of melanoma patients with positive sentinel node biopsy: an Italian melanoma intergroup study (N = 2,086)

The management of melanoma patients with metastatic melanoma in the sentinel nodes (SN) is evolving based on the results of trials questioning the impact of completion lymph node dissection (CLND) and demonstrating the efficacy of new adjuvant treatments. In this landscape, new prognostic tools for...

Full description

Saved in:
Bibliographic Details
Published in:BMC cancer 2022-06, Vol.22 (1), p.610-610, Article 610
Main Authors: Tropea, Saveria, Del Fiore, Paolo, Maurichi, Andrea, Patuzzo, Roberto, Santinami, Mario, Ribero, Simone, Quaglino, Pietro, Caliendo, Virginia, Borgognoni, Lorenzo, Sestini, Serena, Giudice, Giuseppe, Nacchiero, Eleonora, Caracò, Corrado, Cordova, Adriana, Solari, Nicola, Piazzalunga, Dario, Tauceri, Francesca, Carcoforo, Paolo, Lombardo, Maurizio, Cavallari, Sara, Mocellin, Simone
Format: Article
Language:English
Subjects:
Biopsy
Cancer
Clinical trials
Gender
Hypotheses
Lymph nodes
Lymphatic system
Medical prognosis
Melanoma
Metastases
Metastasis
Nomograms
Overall survival
Patients
Prognosis
Prognostic factors
Risk stratification
Statistical analysis
Survival
Treatment of cutaneous melanoma
Tumor burden
Tumor markers
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The management of melanoma patients with metastatic melanoma in the sentinel nodes (SN) is evolving based on the results of trials questioning the impact of completion lymph node dissection (CLND) and demonstrating the efficacy of new adjuvant treatments. In this landscape, new prognostic tools for fine risk stratification are eagerly sought to optimize the therapeutic path of these patients. A retrospective cohort of 2,086 patients treated with CLND after a positive SN biopsy in thirteen Italian Melanoma Centers was reviewed. Overall survival (OS) was the outcome of interest; included independent variables were the following: age, gender, primary melanoma site, Breslow thickness, ulceration, sentinel node tumor burden (SNTB), number of positive SN, non-sentinel lymph nodes (NSN) status. Univariate and multivariate survival analyses were performed using the Cox proportional hazard regression model. The 3-year, 5-year and 10-year OS rates were 79%, 70% and 54%, respectively. At univariate analysis, all variables, except for primary melanoma body site, were found to be statistically significant prognostic factors. Multivariate Cox regression analysis indicated that older age (P 
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-022-09705-y