Mitochondrial components secretion in extracellular vesicles promotes alveolar epithelial mitochondrial quality control

The quality control network in type 2 alveolar epithelial cells (AEC2s) is essential to respond to intrinsic and extrinsic challenges. However, the mechanisms that regulate AEC2 mitochondrial homeostasis remain unclear understood. Here, we report a role of G protein-coupled receptor class C group 5...

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Bibliographic Details
Published in:Nature communications 2025-12, Vol.17 (1), p.833-17, Article 833
Main Authors: Liu, Bowen, Han, Yue, Jin, Yuan, Ye, Meng, Yang, Zeliang, Yang, Jingyi, Zhu, Minglu, Zhao, Xuyang, Jin, Yan, Yin, Yuxin
Format: Article
Language:English
Subjects:
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Alveolar Epithelial Cells - metabolism
Alveoli
Animal models
Animals
Chronic obstructive pulmonary disease
Endosomes
Epithelial cells
Epithelium
Extracellular vesicles
Extracellular Vesicles - metabolism
Homeostasis
Humanities and Social Sciences
Humans
In vivo methods and tests
Injuries
Lung Injury - metabolism
Lung Injury - pathology
Lungs
Maintenance
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mitochondria
Mitochondria - metabolism
multidisciplinary
Physiology
Pulmonary fibrosis
Quality control
Receptors, G-Protein-Coupled - genetics
Receptors, G-Protein-Coupled - metabolism
Science
Science (multidisciplinary)
Secretion
Statistical significance
Vesicles
Citations: Items that this one cites
Online Access:Get full text
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