Pregnancy complicated with hepatitis B virus infection and preterm birth: a retrospective cohort study

Background We aimed to investigate whether maternal chronic hepatitis B virus (HBV) infection affects preterm birth (PTB) in pregnant women. Methods We retrospectively analyzed HBV-infected and non-infected pregnant women attending antenatal care at Fujian Maternity and Child Health Hospital, Fuzhou...

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Bibliographic Details
Published in:BMC pregnancy and childbirth 2021-07, Vol.21 (1), p.1-513, Article 513
Main Authors: Zheng, Shuisen, Zhang, Huale, Chen, Rongxing, Yan, Jianying, Han, Qing
Format: Article
Language:English
Subjects:
Abortion
Body mass index
Childrens health
Cohort analysis
Gestational age
Gestational diabetes
Hepatitis
Hepatitis B
Hepatitis B virus
Hypertension
Hyperthyroidism
Infections
Logistics
Logistics regression
Placental abruption
Preeclampsia
Pregnancy
Premature babies
Premature birth
Preterm birth
Retrospective cohort study
Viruses
Womens health
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Summary:Background We aimed to investigate whether maternal chronic hepatitis B virus (HBV) infection affects preterm birth (PTB) in pregnant women. Methods We retrospectively analyzed HBV-infected and non-infected pregnant women attending antenatal care at Fujian Maternity and Child Health Hospital, Fuzhou, China between January 1, 2016 to December 31, 2018. Participants were divided into HBV infection (n = 1302) and control (n = 12,813) groups. We compared baseline data, pregnancy and perinatal complications, and preterm delivery outcomes between groups. Performed multiple logistics regression analysis to adjust for confounding factors. Finally, we compared early PTB outcome between different HBV DNA level groups. Results The incidence of preterm birth (gestation less than 37 weeks) was similar between the groups, early preterm birth (gestation less than 34 weeks) were significantly more among the HBV infection group than among the controls (1.6% VS. 0.8%; P = 0.003). After adjusting for confounding factors through logistics regression, HBV infection was found to be an independent early PTB risk factor gestation (adjusted odds ratio 1.770; 95% confidence interval [1.046–2.997]). The incidence of early PTB in  2.0 × 10e5 group was not statistically significant (P = 0.417). Conclusion HBV infection is an independent risk factor for early PTB, and the risk did not seem to be influenced by the levels of HBV DNA. Comprehensive programs focusing on pregnant women with HBV infection would reduce the incidence of adverse outcomes.
ISSN:1471-2393
1471-2393
DOI:10.1186/s12884-021-03978-0