The Decreased Growth Hormone Response to Growth Hormone Releasing Hormone in Obesity Is Associated to Cardiometabolic Risk Factors

The aim of the present study was to evaluate the relationship between GHRH-induced GH secretion in obese premenopausal women and cardiovascular risk markers or insulin resistance. Premenopausal obese women, aged 35–52 years, were studied. GH secretion, IGF-I, serum cardiovascular risk markers, insul...

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Bibliographic Details
Published in:Mediators of Inflammation 2010-01, Vol.2010 (2010), p.504-511
Main Authors: Cordido, Fernando, Garcia-Buela, Jesús, Sangiao-Alvarellos, Susana, Martinez, Teresa, Vidal, Ovidio
Format: Article
Language:English
Subjects:
Adipose Tissue
Adult
Cardiovascular diseases
Cardiovascular Diseases - blood
Cardiovascular Diseases - diagnosis
Cholesterol, HDL - metabolism
Cholesterol, LDL - metabolism
Female
Growth Hormone - deficiency
Growth Hormone-Releasing Hormone - metabolism
Health aspects
Human Growth Hormone - metabolism
Humans
Insulin Resistance
Metabolic Syndrome - blood
Metabolic Syndrome - diagnosis
Metabolic syndrome X
Middle Aged
Obesity - complications
Obesity - metabolism
Physiological aspects
Risk Factors
Somatotropin releasing hormone
Women
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Summary:The aim of the present study was to evaluate the relationship between GHRH-induced GH secretion in obese premenopausal women and cardiovascular risk markers or insulin resistance. Premenopausal obese women, aged 35–52 years, were studied. GH secretion, IGF-I, serum cardiovascular risk markers, insulin, leptin, mid-waist and hip circumference, total body fat, and truncal fat were measured. Subjects were classified as meeting the criteria for GH deficiency (GHD) when peak GH after stimulation with GHRH was ≤3 μg/L. Mean total and LDL cholesterol, fasting insulin, and HOMA-IR were all higher, in subjects who would have been classified as GH-deficient compared with GH-sufficient. Peak GH secretion after stimulation was inversely associated with fasting insulin (R=−0.650, P=.012), HOMA-IR (R=−0.846, P=.001), total cholesterol (R=−0.532, P=.034), and LDL cholesterol (R=−0.692, P=.006) and positively associated with HDL cholesterol (R=0.561, P=.037). These data strongly suggest a role for insulin resistance in the decreased GH secretion of obesity and that the blunted GH secretion of central obesity could be the pituitary expression of the metabolic syndrome.
ISSN:0962-9351
1466-1861
DOI:10.1155/2010/434562