Clinical and Prognostic Significance of Baseline Serum Vitamin D Levels in Hospitalized Egyptian Covid-19 Patients

Background and Aim: Vitamin D is a hormone with essential roles in both cellular metabolism and immunity. It controls calcium homeostasis and modulates innate and adaptive immune system responses. Many studies suggested an association between vitamin D deficiency and clinical outcomes of covid-19 in...

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Published in:International journal of general medicine 2022-11, Vol.15, p.8063-8070
Main Authors: Mostafa, Sadek, Mohammed, Shaymaa A, Elshennawy, Salwa I, Zakaria, Doaa Mohammed, Mahmoud, Sammar Ahmed Kasim, Alsadek, Amira Mohammed, Ahmad, Inass Hassan, Mohammed, Doaa Sayed, Mohammed, Marwa Abdelmonim, Eltrawy, Heba H
Format: Article
Language:English
Subjects:
Alfacalcidol
Automation
Calcifediol
Coronaviruses
Correlation analysis
COVID-19
Egypt
Ethylenediaminetetraacetic acid
Ferritin
Health aspects
Hospital patients
Hospitalization
Infection
Infections
Laboratories
Metabolism
Mortality
Original Research
Physiological aspects
Regression analysis
Severe acute respiratory syndrome coronavirus 2
Ventilators
Vitamin D
vitamin d deficiency
Vitamin deficiency
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container_title International journal of general medicine
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creator Mostafa, Sadek
Mohammed, Shaymaa A
Elshennawy, Salwa I
Zakaria, Doaa Mohammed
Mahmoud, Sammar Ahmed Kasim
Alsadek, Amira Mohammed
Ahmad, Inass Hassan
Mohammed, Doaa Sayed
Mohammed, Marwa Abdelmonim
Eltrawy, Heba H
description Background and Aim: Vitamin D is a hormone with essential roles in both cellular metabolism and immunity. It controls calcium homeostasis and modulates innate and adaptive immune system responses. Many studies suggested an association between vitamin D deficiency and clinical outcomes of covid-19 infection, while others failed to document such a relation. The present study aimed to evaluate the clinical and prognostic significance of baseline vitamin D levels in hospitalized Egyptian covid-19 patients. Patients and Methods: The present retrospective study included 300 hospitalized covid-19 patients. Patients were submitted to standard clinical, laboratory, and radiological assessment. According to vitamin D levels, patients were classified to have normal levels ([greater than or equal to]30), insufficient levels (20-29) or deficient levels (
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It controls calcium homeostasis and modulates innate and adaptive immune system responses. Many studies suggested an association between vitamin D deficiency and clinical outcomes of covid-19 infection, while others failed to document such a relation. The present study aimed to evaluate the clinical and prognostic significance of baseline vitamin D levels in hospitalized Egyptian covid-19 patients. Patients and Methods: The present retrospective study included 300 hospitalized covid-19 patients. Patients were submitted to standard clinical, laboratory, and radiological assessment. According to vitamin D levels, patients were classified to have normal levels ([greater than or equal to]30), insufficient levels (20-29) or deficient levels (&lt;20). Results: According to their vitamin D levels, patients were classified into those with normal vitamin D (n=135), others with vitamin D insufficiency (n=114), and a third group with vitamin D deficiency (n=51). Patients with normal vitamin D levels and vitamin D insufficiency are significantly younger [median (IQR): 49.0 (39.0-57.0) versus 51.0 (40.0-61.0) and 55.0 (43.0-62.0 (years, respectively, p=0.012] and had less frequency of severe disease (24.4% versus 40.4% and 51.0%, respectively (when compared with those with vitamin D deficiency. Moreover, they had significantly lower levels of D dimer [median (IQR): 1.5 (0.9-2.5 (versus 1.8 (0.9-3.1) and 2.0 (1.0-3.2)], CRP [median (IQR): 58.0 (30.0-120.0 (versus 76.0 (42.5-160.0) and 105.0 (74.0-208.0), respectively, p&lt;0.001], ferritin [median (IQR): 458.0 (240.0-759.0 (versus 606.0 (433.8-897.8) and 820.0 (552.0-1087.0), respectively, p&lt;0.001], and procalcitonin [median (IQR): 290.0 (152.0-394.0 (versus 372.5 (227.0-530.5) and 443.0 (272.0-575.0), respectively, p&lt;0.001]. Only lower vitamin D levels were significant predictors of mortality in multivariate analysis [OR (95% CI): 0.88 (0.84-0.92), p&lt;0.001]. Conclusion: Low vitamin D levels are related to exaggerated inflammatory response, disease severity, and poor clinical outcome in hospitalized covid-19 patients. Keywords: covid-19, vitamin D, vitamin D deficiency</description><identifier>ISSN: 1178-7074</identifier><identifier>EISSN: 1178-7074</identifier><identifier>DOI: 10.2147/IJGM.S386815</identifier><language>eng</language><publisher>Macclesfield: Dove Medical Press Limited</publisher><subject>Alfacalcidol ; Automation ; Calcifediol ; Coronaviruses ; Correlation analysis ; COVID-19 ; Egypt ; Ethylenediaminetetraacetic acid ; Ferritin ; Health aspects ; Hospital patients ; Hospitalization ; Infection ; Infections ; Laboratories ; Metabolism ; Mortality ; Original Research ; Physiological aspects ; Regression analysis ; Severe acute respiratory syndrome coronavirus 2 ; Ventilators ; Vitamin D ; vitamin d deficiency ; Vitamin deficiency</subject><ispartof>International journal of general medicine, 2022-11, Vol.15, p.8063-8070</ispartof><rights>COPYRIGHT 2022 Dove Medical Press Limited</rights><rights>2022. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Mostafa et al. 2022 Mostafa et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c651t-8f863f0e82b3c434c798d9e745519d09ffe2cb8518084f9495a9b22fcdf3020a3</citedby><cites>FETCH-LOGICAL-c651t-8f863f0e82b3c434c798d9e745519d09ffe2cb8518084f9495a9b22fcdf3020a3</cites><orcidid>0000-0002-1261-6748 ; 0000-0001-7477-8833 ; 0000-0003-0067-9490</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2736959650/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2736959650?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,38516,43895,44590,53791,53793,74412,75126</link.rule.ids></links><search><creatorcontrib>Mostafa, Sadek</creatorcontrib><creatorcontrib>Mohammed, Shaymaa A</creatorcontrib><creatorcontrib>Elshennawy, Salwa I</creatorcontrib><creatorcontrib>Zakaria, Doaa Mohammed</creatorcontrib><creatorcontrib>Mahmoud, Sammar Ahmed Kasim</creatorcontrib><creatorcontrib>Alsadek, Amira Mohammed</creatorcontrib><creatorcontrib>Ahmad, Inass Hassan</creatorcontrib><creatorcontrib>Mohammed, Doaa Sayed</creatorcontrib><creatorcontrib>Mohammed, Marwa Abdelmonim</creatorcontrib><creatorcontrib>Eltrawy, Heba H</creatorcontrib><title>Clinical and Prognostic Significance of Baseline Serum Vitamin D Levels in Hospitalized Egyptian Covid-19 Patients</title><title>International journal of general medicine</title><description>Background and Aim: Vitamin D is a hormone with essential roles in both cellular metabolism and immunity. It controls calcium homeostasis and modulates innate and adaptive immune system responses. Many studies suggested an association between vitamin D deficiency and clinical outcomes of covid-19 infection, while others failed to document such a relation. The present study aimed to evaluate the clinical and prognostic significance of baseline vitamin D levels in hospitalized Egyptian covid-19 patients. Patients and Methods: The present retrospective study included 300 hospitalized covid-19 patients. Patients were submitted to standard clinical, laboratory, and radiological assessment. According to vitamin D levels, patients were classified to have normal levels ([greater than or equal to]30), insufficient levels (20-29) or deficient levels (&lt;20). Results: According to their vitamin D levels, patients were classified into those with normal vitamin D (n=135), others with vitamin D insufficiency (n=114), and a third group with vitamin D deficiency (n=51). Patients with normal vitamin D levels and vitamin D insufficiency are significantly younger [median (IQR): 49.0 (39.0-57.0) versus 51.0 (40.0-61.0) and 55.0 (43.0-62.0 (years, respectively, p=0.012] and had less frequency of severe disease (24.4% versus 40.4% and 51.0%, respectively (when compared with those with vitamin D deficiency. Moreover, they had significantly lower levels of D dimer [median (IQR): 1.5 (0.9-2.5 (versus 1.8 (0.9-3.1) and 2.0 (1.0-3.2)], CRP [median (IQR): 58.0 (30.0-120.0 (versus 76.0 (42.5-160.0) and 105.0 (74.0-208.0), respectively, p&lt;0.001], ferritin [median (IQR): 458.0 (240.0-759.0 (versus 606.0 (433.8-897.8) and 820.0 (552.0-1087.0), respectively, p&lt;0.001], and procalcitonin [median (IQR): 290.0 (152.0-394.0 (versus 372.5 (227.0-530.5) and 443.0 (272.0-575.0), respectively, p&lt;0.001]. Only lower vitamin D levels were significant predictors of mortality in multivariate analysis [OR (95% CI): 0.88 (0.84-0.92), p&lt;0.001]. Conclusion: Low vitamin D levels are related to exaggerated inflammatory response, disease severity, and poor clinical outcome in hospitalized covid-19 patients. Keywords: covid-19, vitamin D, vitamin D deficiency</description><subject>Alfacalcidol</subject><subject>Automation</subject><subject>Calcifediol</subject><subject>Coronaviruses</subject><subject>Correlation analysis</subject><subject>COVID-19</subject><subject>Egypt</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Ferritin</subject><subject>Health aspects</subject><subject>Hospital patients</subject><subject>Hospitalization</subject><subject>Infection</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Metabolism</subject><subject>Mortality</subject><subject>Original Research</subject><subject>Physiological aspects</subject><subject>Regression analysis</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Ventilators</subject><subject>Vitamin D</subject><subject>vitamin d deficiency</subject><subject>Vitamin deficiency</subject><issn>1178-7074</issn><issn>1178-7074</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>COVID</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12LEzEUQAdRcF198wcEBPHB1nxNJnkR1rruViouVH0NmczNNMs0qZOZwvrrTW3RVmSRPCTcnJzLTXKL4jnBU0p49Wb-8erTdMmkkKR8UJwRUslJhSv-8Gj9uHiS0i3GQgjCzop-1vngremQCQ266WMbYhq8RUvfBu_yTrCAokPvTIKMAlpCP67RNz-YtQ_oPVrAFrqE8vo6pk0Od_4HNOiyvdsM3gQ0i1vfTIhCN2bwEIb0tHjkTJfg2WE-L75-uPwyu54sPl_NZxeLiRUlGSbSScEcBklrZjnjtlKyUVDxsiSqwco5oLaWJZFYcqe4Ko2qKXW2cQxTbNh5Md97m2hu9ab3a9Pf6Wi8_hWIfatNn0vtQDNpwNR1owgF7iitiQDrMJcC11iCzK63e9dmrNfQ2FxHb7oT6elO8Cvdxq1WuRZcqSx4dRD08fsIadBrnyx0nQkQx6RpxSouuKIsoy_-Qm_j2Id8VTtKqDI78R-qNbkAH1zMee1Oqi_yjQhKmRD3UhXDJS_zv8jU9B9UHg2svY0BnM_xE-1_HTjO8PLowApMN6xS7MbBx5BOzfeCx8bXe9D2MaUe3O_HIFjvukHvukEfuoH9BPBk-Io</recordid><startdate>20221130</startdate><enddate>20221130</enddate><creator>Mostafa, Sadek</creator><creator>Mohammed, Shaymaa A</creator><creator>Elshennawy, Salwa I</creator><creator>Zakaria, Doaa Mohammed</creator><creator>Mahmoud, Sammar Ahmed Kasim</creator><creator>Alsadek, Amira Mohammed</creator><creator>Ahmad, Inass Hassan</creator><creator>Mohammed, Doaa Sayed</creator><creator>Mohammed, Marwa Abdelmonim</creator><creator>Eltrawy, Heba H</creator><general>Dove Medical Press Limited</general><general>Taylor &amp; 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It controls calcium homeostasis and modulates innate and adaptive immune system responses. Many studies suggested an association between vitamin D deficiency and clinical outcomes of covid-19 infection, while others failed to document such a relation. The present study aimed to evaluate the clinical and prognostic significance of baseline vitamin D levels in hospitalized Egyptian covid-19 patients. Patients and Methods: The present retrospective study included 300 hospitalized covid-19 patients. Patients were submitted to standard clinical, laboratory, and radiological assessment. According to vitamin D levels, patients were classified to have normal levels ([greater than or equal to]30), insufficient levels (20-29) or deficient levels (&lt;20). Results: According to their vitamin D levels, patients were classified into those with normal vitamin D (n=135), others with vitamin D insufficiency (n=114), and a third group with vitamin D deficiency (n=51). Patients with normal vitamin D levels and vitamin D insufficiency are significantly younger [median (IQR): 49.0 (39.0-57.0) versus 51.0 (40.0-61.0) and 55.0 (43.0-62.0 (years, respectively, p=0.012] and had less frequency of severe disease (24.4% versus 40.4% and 51.0%, respectively (when compared with those with vitamin D deficiency. Moreover, they had significantly lower levels of D dimer [median (IQR): 1.5 (0.9-2.5 (versus 1.8 (0.9-3.1) and 2.0 (1.0-3.2)], CRP [median (IQR): 58.0 (30.0-120.0 (versus 76.0 (42.5-160.0) and 105.0 (74.0-208.0), respectively, p&lt;0.001], ferritin [median (IQR): 458.0 (240.0-759.0 (versus 606.0 (433.8-897.8) and 820.0 (552.0-1087.0), respectively, p&lt;0.001], and procalcitonin [median (IQR): 290.0 (152.0-394.0 (versus 372.5 (227.0-530.5) and 443.0 (272.0-575.0), respectively, p&lt;0.001]. Only lower vitamin D levels were significant predictors of mortality in multivariate analysis [OR (95% CI): 0.88 (0.84-0.92), p&lt;0.001]. Conclusion: Low vitamin D levels are related to exaggerated inflammatory response, disease severity, and poor clinical outcome in hospitalized covid-19 patients. Keywords: covid-19, vitamin D, vitamin D deficiency</abstract><cop>Macclesfield</cop><pub>Dove Medical Press Limited</pub><doi>10.2147/IJGM.S386815</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-1261-6748</orcidid><orcidid>https://orcid.org/0000-0001-7477-8833</orcidid><orcidid>https://orcid.org/0000-0003-0067-9490</orcidid><oa>free_for_read</oa></addata></record>
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source Taylor & Francis Open Access; Publicly Available Content Database; PubMed Central; Coronavirus Research Database
subjects Alfacalcidol
Automation
Calcifediol
Coronaviruses
Correlation analysis
COVID-19
Egypt
Ethylenediaminetetraacetic acid
Ferritin
Health aspects
Hospital patients
Hospitalization
Infection
Infections
Laboratories
Metabolism
Mortality
Original Research
Physiological aspects
Regression analysis
Severe acute respiratory syndrome coronavirus 2
Ventilators
Vitamin D
vitamin d deficiency
Vitamin deficiency
title Clinical and Prognostic Significance of Baseline Serum Vitamin D Levels in Hospitalized Egyptian Covid-19 Patients
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