Moyamoya disease: A human model for chronic hypoperfusion and intervention in Alzheimer's disease

Introduction Chronic cerebral hypoperfusion has been considered the etiology for sporadic Alzheimer's disease (AD). However, no valid clinical evidence exists due to the similar risk factors between cerebrovascular disease and AD. Methods We used moyamoya disease (MMD) as a model of chronic hyp...

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Published in:Alzheimer's & dementia : translational research & clinical interventions 2022, Vol.8 (1), p.e12285-n/a
Main Authors: Zou, Xiang, Yuan, Yifan, Liao, Yujun, Jiang, Conglin, Zhao, Fan, Ding, Ding, Gu, Yuxiang, Chen, Liang, Chu, Ying‐Hua, Hsu, Yi‐Cheng, Liebig, Patrick Alexander, Xu, Bin, Mao, Ying
Format: Article
Language:English
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Alzheimer's disease
Atherosclerosis
Brain
Cerebrovascular disease
Cognitive ability
cognitive impairment
Dementia
Homeostasis
hypoperfusion
Hypotheses
Magnetic resonance imaging
metabolism
moyamoya disease
Pathogenesis
Pathology
revascularization
Stroke
Veins & arteries
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Summary:Introduction Chronic cerebral hypoperfusion has been considered the etiology for sporadic Alzheimer's disease (AD). However, no valid clinical evidence exists due to the similar risk factors between cerebrovascular disease and AD. Methods We used moyamoya disease (MMD) as a model of chronic hypoperfusion and cognitive impairment, without other etiology interference. Results Based on the previous reports and preliminary findings, we hypothesized that chronic cerebral hypoperfusion could be an independent upstream crucial variable, resulting in AD, and induce pathological hallmarks such as amyloid beta peptide and hyperphosphorylated tau accumulation. Discussion Timely intervention with revascularisation would help reverse the brain damage with AD hallmarks and lead to cognitive improvement.
ISSN:2352-8737
2352-8737
DOI:10.1002/trc2.12285