Falcaria vulgaris extract attenuates ethanol-induced renal damage by reducing oxidative stress and lipid peroxidation in rats

Background: Alcohol consumption is capable of producing free radicals and inducing disturbance in body antioxidant. Falcaria vulgaris (F. vulgaris) is a vegetable and it has beneficial antioxidant effects. Materials and Methods: Forty-eight Wistar rats were divided randomly into eight groups (n = 6)...

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Bibliographic Details
Published in:Journal of pharmacy & bioallied science 2019-07, Vol.11 (3), p.268-275
Main Authors: Jalili, Cyrus, Roshankhah, Shiva, Salahshoor, Mohammad
Format: Article
Language:English
Subjects:
Alcohol
Alcohol, Denatured
Antioxidants
Body weight
Corpuscles
Creatinine
Deoxyribonucleic acid
DNA
Drug dosages
Ethanol
Falcaria vulgaris
Free radicals
Kidneys
Laboratory animals
Lipid peroxidation
Lipids
Malondialdehyde
Original
Oxidative stress
renal damage
Studies
Ulcers
Urea
Zinc sulfate
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Summary:Background: Alcohol consumption is capable of producing free radicals and inducing disturbance in body antioxidant. Falcaria vulgaris (F. vulgaris) is a vegetable and it has beneficial antioxidant effects. Materials and Methods: Forty-eight Wistar rats were divided randomly into eight groups (n = 6): control normal (saline) and ethanol (5g EtOH/kg body weight/24h) control groups, F. vulgaris groups (50, 100, and 150mg/kg), and F. vulgaris + ethanol treated groups (50, 100, and 150mg/kg). Treatments were administered intraperitoneally and through gavage daily for 12 weeks. Parameters related to the function and the histology of the kidneys were evaluated and statistically analyzed from kidney and blood serum samples with respect to the groups. Results: Ethanol administration increased significantly Bowman's space, qualitative histopathology indices, kidney malondialdehyde (MDA) level, blood urea nitrogen (BUN), creatinine, and nitrite oxide levels and decreased significantly total antioxidant capacity (TAC) level and diameter and number of renal corpuscles compared to that in the control normal group (P < 0.001). The F. vulgaris and F. vulgaris + ethanol treatments in a dose-dependent manner reduced significantly Bowman's space, qualitative histopathology indices, kidney MDA level, BUN, creatinine, and nitrite oxide levels and increased significantly TAC level and diameter and number of renal corpuscles compared to that in the ethanol normal group (P < 0.001). Conclusion: It seems that F. vulgaris administration in a dose-dependent manner improved kidney injury induced by ethanol in rats.
ISSN:0975-7406
0976-4879
0975-7406
DOI:10.4103/jpbs.JPBS_134_19