A sex-dependent salivary bacterium influences oral mucositis severity after allogeneic hematopoietic cell transplantation

The success of allogeneic hematopoietic cell transplantation (alloHCT) in curing hematologic disorders is limited by its short- and long-term toxicities. One such toxicity is oral mucositis (OM), causing pain, speech/swallowing difficulty, and prolonged hospitalization. Although conditioning chemora...

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Bibliographic Details
Published in:NPJ biofilms and microbiomes 2024-11, Vol.10 (1), p.140-11, Article 140
Main Authors: Gem, Hakan, Ebadi, Maryam, Sebastian, Gale, Abasaeed, Rania, Lloid, Michele, Minot, Samuel S., Dean, David R., Rashidi, Armin
Format: Article
Language:English
Subjects:
631/326/2565/2134
692/700/3032/3039/3049
Adult
Aged
Allografts
Biofilms
Biomedical and Life Sciences
Cancer
Chemoradiotherapy
Female
Hematological diseases
Hematopoietic Stem Cell Transplantation - adverse effects
Hematopoietic stem cells
Humans
Introduced species
Life Sciences
Male
Medical Microbiology
Microbial Ecology
Microbial Genetics and Genomics
Microbiology
Microbiota
Microorganisms
Middle Aged
Mucositis
Pathogenesis
Patients
Saliva
Saliva - microbiology
Severity of Illness Index
Sex
Sex Factors
Stem cell transplantation
Stomatitis - etiology
Stomatitis - microbiology
Toxicity
Transplantation
Transplantation, Homologous - adverse effects
Uric acid
Uric Acid - analysis
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Summary:The success of allogeneic hematopoietic cell transplantation (alloHCT) in curing hematologic disorders is limited by its short- and long-term toxicities. One such toxicity is oral mucositis (OM), causing pain, speech/swallowing difficulty, and prolonged hospitalization. Although conditioning chemoradiotherapy is the direct cause of OM, potential host-intrinsic mediators of mucosal injury remain elusive. We hypothesized that the oral microbiota may influence OM severity. We used a validated comprehensive scoring system based on specialized Oral Medicine examinations to longitudinally quantify OM severity in alloHCT recipients. High-throughput multi-site profiling of the oral microbiota was performed in parallel. We identify a sex-dependent commensal bacterium, Oribacterium asaccharolyticum , whose presence in saliva before transplantation is associated with more severe OM 14 days after transplantation. The sex predilection of this species correlated with higher uric acid levels in men. Our findings represent the first sex-dependent microbiota-mediated pathway in OM pathogenesis and introduce novel targets for preventative interventions.
ISSN:2055-5008
2055-5008
DOI:10.1038/s41522-024-00611-8