Quantification of irrigated lesion morphology using near-infrared spectroscopy

There are currently limited means by which lesion formation can be confirmed during radiofrequency ablation procedures. The purpose of this study was to evaluate the use of NIRS-integrated RFA catheters for monitoring irrigated lesion progression, ex vivo and in vivo. Open-irrigated NIRS-ablation ca...

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Bibliographic Details
Published in:Scientific reports 2021-10, Vol.11 (1), p.20160-20160, Article 20160
Main Authors: Park, Soo Young, Singh-Moon, Rajinder, Yang, Haiqiu, Saluja, Deepak, Hendon, Christine
Format: Article
Language:English
Subjects:
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Ablation
Animals
Cardiovascular Surgical Procedures - methods
Catheter Ablation - methods
Catheters
Heart Diseases - diagnostic imaging
Heart Diseases - pathology
Heart Diseases - surgery
Humanities and Social Sciences
Infrared spectroscopy
Lesions
Medical instruments
multidisciplinary
Prediction models
Radiofrequency ablation
Science
Science (multidisciplinary)
Spectroscopy, Near-Infrared - methods
Spectrum analysis
Swine
Therapeutic Irrigation - methods
Treatment Outcome
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Summary:There are currently limited means by which lesion formation can be confirmed during radiofrequency ablation procedures. The purpose of this study was to evaluate the use of NIRS-integrated RFA catheters for monitoring irrigated lesion progression, ex vivo and in vivo. Open-irrigated NIRS-ablation catheters with optical fibers were fabricated to sample tissue diffuse reflectance. Spectra from 44 irrigated lesions and 44 non-lesion sites from ex vivo swine hearts (n = 15) were used to train and evaluate a predictive model for lesion dimensions based on key spectral features. Additional studies were performed in diluted blood to assess NIRS signatures of catheter-tissue contact status. Finally, the potential of NIRS-RFA catheters for guiding lesion delivery was evaluated in a set of in vivo pilot studies conducted in healthy pigs (n = 4). Model predictions for lesion depth ( R  = 0.968), width ( R  = 0.971), and depth percentage ( R  = 0.924) correlated well with measured lesion dimensions. In vivo deployment in preliminary trials showed robust translational consistency of contact discrimination (P 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-99725-8