Computed tomography after severe COVID-19 pneumonia: findings at 6 months and beyond

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects the alveolar epithelial cells causing coronavirus disease (COVID-19) pneumonia of varying severity [1, 2]. 15–30% of patients develop acute respiratory distress syndrome (ARDS) requiring hospitalisation in intensive care units (ICU...

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Published in:ERJ open research 2021-10, Vol.7 (4), p.488
Main Authors: Poitevineau, Thibaud, Chassagnon, Guillaume, Bouam, Samir, Jaubert, Paul, Cheurfa, Chérifa, Regard, Lucile, Canniff, Emma, Dinh-Xuan, Anh Tuan, Revel, Marie-Pierre
Format: Article
Language:English
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Research Letters
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Summary:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects the alveolar epithelial cells causing coronavirus disease (COVID-19) pneumonia of varying severity [1, 2]. 15–30% of patients develop acute respiratory distress syndrome (ARDS) requiring hospitalisation in intensive care units (ICU) and mechanical ventilation [2, 3]. At 3 months, there are persisting computed tomography (CT) abnormalities in 17 to 91% of discharged COVID-19 patients [4–8], mainly consistent with an organising pneumonia (OP) pattern. These anomalies are more frequently reported in patients who were admitted to ICU [9]. Pulmonary fibrosis has been reported at autopsy of patients deceased from COVID-19 pneumonia, along with pulmonary microvascular thrombosis [10]. Parenchymal bands and ground-glass opacities consistent with a pattern of late organising pneumonia are frequently observed 6 months after ICU admission for #COVID19, whereas fibrotic changes of limited extent are only observed in about 1/3 of patients https://bit.ly/2UGOsbr
ISSN:2312-0541
2312-0541
DOI:10.1183/23120541.00488-2021