Revised Temperament and Character Inventory factors predict neuropsychiatric symptoms and aging-related cognitive decline across 25 years

• Published in: Frontiers in aging neuroscience 2024-02, Vol.16, p.1335336-1335336
• Main Authors: Ronat, Lucas, Rönnlund, Michael, Adolfsson, Rolf, Hanganu, Alexandru, Pudas, Sara
• Format: Article
• Language: English
• Subjects: Aging; Aging Neuroscience; Alzheimer's disease; Alzheimer’s dementia; Anxiety; Apathy; Apolipoprotein E; Cardiovascular diseases; Cognition; Cognition & reasoning; Cognitive ability; cognitive decline; Dementia; Dementia disorders; Diabetes mellitus; Health risk assessment; Hippocampus; longitudinal study; Memory; Mental depression; Mental disorders; Middle age; MRI; Neurodegenerative diseases; Neuroimaging; neuropsychiatric symptoms; Neurosis; Personality; Personality traits; Population studies; Regression analysis; Risk factors
• ISSN: 1663-4365; 1663-4365
• DOI: 10.3389/fnagi.2024.1335336

Personality traits and neuropsychiatric symptoms such as neuroticism and depression share genetic overlap and have both been identified as risks factors for development of aging-related neurocognitive decline and Alzheimer's disease (AD). This study aimed to examine revised personality factors derived from the Temperament and Character Inventory, previously shown to be associated with psychiatric disorders, as predictors of neuropsychiatric, cognitive, and brain trajectories of participants from a population-based aging study. Mixed-effect linear regression analyses were conducted on data for the full sample (  = 1,286), and a healthy subsample not converting to AD-dementia during 25-year follow-up (  = 1,145), complemented with Cox proportional regression models to determine risk factors for conversion to clinical AD. Two personality factors, (CE: avoidance of new stimuli, high anxiety, pessimistic anticipation, low reward seeking) and (TL: inability to change, low autonomy, unaware of the value of their existence) were associated with higher levels of depressive symptoms, stress (CE), sleep disturbance (TL), as well as greater decline in memory, vocabulary and verbal fluency in the full sample. Higher CE was additionally associated with greater memory decline across 25 years in the healthy subsample, and faster right hippocampal volume reduction across 8 years in a neuroimaging subsample (  = 216). Most, but not all, personality-cognition associations persisted after controlling for diabetes, hypertension and cardiovascular disease. Concerning risks for conversion to AD, higher age, and -ε4, but none of the personality measures, were significant predictors. The results indicate that personality traits associated with psychiatric symptoms predict accelerated age-related neurocognitive declines even in the absence of neurodegenerative disease. The attenuation of some personality effects on cognition after adjustment for health indicators suggests that those effects may be partly mediated by somatic health. Taken together, the results further emphasize the importance of personality traits in neurocognitive aging and underscore the need for an integrative (biopsychosocial) perspective of normal and pathological age-related cognitive decline.