A study of the catalytic role of a gold electrode in the electrochemical activation of four macrolide antibiotics in sodium bicarbonate solution

Using the cyclic voltammetry, it has been shown that hydrogen evolution at a gold electrode is necessary in the electrochemical activation of azithromycin dihydrate and erythromycin A. After four hours of the potential holding at -1.2 V vs. SCE, the pH of the electrolyte has been changed from 8.40 t...

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Bibliographic Details
Published in:Chemical Industry and Chemical Engineering Quarterly 2010-07, Vol.16 (2), p.111-116
Main Authors: Avramov-Ivic, Milka, Petrovic, Slobodan, Zivkovic, Predrag, Mijin, Dusan, Drljevic, Katica
Format: Article
Language:English
Subjects:
catalytic role
gold electrode
macrolide antibiotics
spectroscopy
UV-Vis
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Summary:Using the cyclic voltammetry, it has been shown that hydrogen evolution at a gold electrode is necessary in the electrochemical activation of azithromycin dihydrate and erythromycin A. After four hours of the potential holding at -1.2 V vs. SCE, the pH of the electrolyte has been changed from 8.40 to 8.96; from 8.40 to 8.77 in the presence of erythromycin A, and from 8.40 to 9.18 in the presence of azithromycin, indicating the reaction of the hydrogen species with antibiotics. This effect has been confirmed by using the phenolphthalein indicator and by analysing colours of the solutions by UV-Vis, as well as by FTIR spectroscopy. Under the identical experimental conditions at the gold electrode, in contrast to azithromycin dihydrate and erythromycin A, roxithromycin and midecamycin electroactivity promotion has been obtained during the first forward sweep starting from the area of a double layer region. nema
ISSN:1451-9372
2217-7434
DOI:10.2298/CICEQ091211017A